SCQ1

SCQ1
Identifiers
	IUPAC name (S)-spiro[4-azabicyclo[2.2.2]octane-2,2'-benzo[h]chromen]-4'(3'H)-one;
ChemSpider	88790995;
Chemical and physical data
Formula	C19H19NO2
Molar mass	293.366 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C3C[C@@]1(CN2CCC1CC2)Oc4c3ccc5ccccc45;

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(S)-SCQ1 is a drug which acts as a potent and selective antagonist for the 5-HT_2B and 5-HT_2C serotonin receptors, but with only modest affinity for the closely related 5-HT_2A receptor and other targets such as 5-HT₇. Since most currently available 5-HT₂ class ligands have relatively poor selectivity and bind to all three subtypes, the selectivity of (S)-SCQ1 is expected to be useful for studying 5-HT_2A receptor mediated responses in the absence of 5-HT_2B and 5-HT_2C activation.^[1]

References

^ Yao R, Jensen AA, Bryce-Rogers HP, Schultz-Knudsen K, Zhou L, Hovendal NP, et al. (August 2023). "Identification of 5-HT2 Serotonin Receptor Modulators through the Synthesis of a Diverse, Tropane- and Quinuclidine-alkaloid-Inspired Compound Library". Journal of Medicinal Chemistry. 66 (16): 11536–11554. doi:10.1021/acs.jmedchem.3c01059. PMID 37566000. S2CID 260806387.

[pmid37566000-1] Yao R, Jensen AA, Bryce-Rogers HP, Schultz-Knudsen K, Zhou L, Hovendal NP, et al. (August 2023). "Identification of 5-HT2 Serotonin Receptor Modulators through the Synthesis of a Diverse, Tropane- and Quinuclidine-alkaloid-Inspired Compound Library". Journal of Medicinal Chemistry. 66 (16): 11536–11554. doi:10.1021/acs.jmedchem.3c01059. PMID 37566000. S2CID 260806387.

[1]

See also

References