Concentrative nucleoside transporter
(Redirected from Concentrative nucleoside transporters)
| Nucleos_tra2_C | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Nucleos_tra2_C | ||||||||
| Pfam | PF07662 | ||||||||
| InterPro | IPR011657 | ||||||||
| TCDB | 2.A.41 | ||||||||
| OPM superfamily | 388 | ||||||||
| OPM protein | 3tij | ||||||||
| |||||||||
Human concentrative nucleoside transporters include SLC28A1, SLC28A2 and SLC28A3 proteins. SLC28A2 is a purine-specific Na+-nucleoside cotransporter localised to the bile canalicular membrane.[1] SLC28A1 is a Na+-dependent nucleoside transporter selective for pyrimidine nucleosides and adenosine. It also transports the anti-viral nucleoside analogues Zidovudine and Zalcitabine.[2]
References
[edit]- ^ Che M, Ortiz DF, Arias IM (Jun 1995). "Primary structure and functional expression of a cDNA encoding the bile canalicular, purine-specific Na(+)-nucleoside cotransporter". The Journal of Biological Chemistry. 270 (23): 13596–9. doi:10.1074/jbc.270.23.13596. PMID 7775409.
- ^ Huang QQ, Yao SY, Ritzel MW, Paterson AR, Cass CE, Young JD (Jul 1994). "Cloning and functional expression of a complementary DNA encoding a mammalian nucleoside transport protein". The Journal of Biological Chemistry. 269 (27): 17757–60. doi:10.1016/S0021-9258(17)32370-0. PMID 8027026.