Cytoprotection
Cytoprotection is a process by which chemical compounds or shells around cells provide protection to cells against harmful agents.[1][2]
Gastric cytoprotectant
[edit]A gastric cytoprotectant is any medication that combats ulcers not by reducing gastric acid but by increasing mucosal protection.[citation needed] Examples of gastric cytoprotective agents include prostaglandins which protect the stomach mucosa against injury by increasing gastric mucus secretion. Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit the synthesis of prostaglandins and thereby make the stomach more susceptible to injury.[3] Gastric cytoprotective drugs include carbenoxolone, deglycyrrhizinised liquorice, sucralfate (aluminium hydroxide and sulphated sucrose), misoprostol (a prostaglandin analogue), bismuth chelate (tri-potassium di-citrato bismuthate) and zinc L-carnosine.
References
[edit]- ^ "MeSH Heading: Cytoprotection". Medical Subject Headings. United States National Library of Medicine.
- ^ Rheem, Hyeong Bin; Kim, Nayoung; Nguyen, Duc Tai; Baskoro, Ghanyatma Adi; Roh, Jihun H.; Lee, Jungkyu K.; Kim, Beom Jin; Choi, Insung S. (2025-05-22). "Single-Cell Nanoencapsulation: Chemical Synthesis of Artificial Cell-in-Shell Spores". Chemical Reviews. doi:10.1021/acs.chemrev.4c00984. ISSN 0009-2665.
- ^ Wallace JL (September 1992). "Prostaglandins, NSAIDs, and cytoprotection". Gastroenterol. Clin. North Am. 21 (3): 631–41. doi:10.1016/S0889-8553(21)00052-2. PMID 1516961.
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