File:DNA Methylation - How Does it Cause Cancer (1).svg
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Summary
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English: Global hypomethylation is when methyl groups do not bond to CpG islands, causing an oncogene to be expressed when it otherwise should not be. In the diagram, cell 1 is cancer-free as it is not experiencing hypomethylation. Then, we see an example of hypomethylation where methyl groups do not bond, causing the expression of an oncogene and thus inducing cancer development.
Methylation can also silence a tumor suppressor gene. In the diagram, we see that cell 3 is cancer-free, as there is no hypermethylation,n meaning methyl groups are not actively bound and silencing a tumor suppressor gene. In cell 4, it is cancerous due to hypermethylation, causing the tumor suppressor gene to not be expressed. Source: Chen Chen, Zehua Wang, Yi Ding, Lei Wang, Siyuan Wang, Haonan Wang, Yanru Qin. DNA Methylation: From Cancer Biology to Clinical Perspectives. Front. Biosci. (Landmark Ed) 2022, 27(12), 326. https://doi.org/10.31083/j.fbl2712326 |
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| Source | Own work |
| Author | Seamac10 |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
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| current | 15:24, 4 June 2025 | | 512 × 231 (256 KB) | Seamac10 | Uploaded own work with UploadWizard |
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