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Protein-coding gene in the species Homo sapiens
Sorting nexin-18 is a protein that in humans is encoded by the SNX18 gene .[ 5] [ 6] [ 7]
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a SH3 domain . The specific function of this protein has not been determined.[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000178996 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042364 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Seet LF, Hong W (Sep 2006). "The Phox (PX) domain proteins and membrane traffic". Biochim Biophys Acta . 1761 (8): 878– 96. doi :10.1016/j.bbalip.2006.04.011 . PMID 16782399 . ^ Thornhill PB, Cohn JB, Drury G, Stanford WL, Bernstein A, Desbarats J (Sep 2007). "A proteomic screen reveals novel Fas ligand interacting proteins within nervous system Schwann cells" . FEBS Lett . 581 (23): 4455– 62. doi :10.1016/j.febslet.2007.08.025 PMID 17761170 . S2CID 23223511 . ^ a b "Entrez Gene: SNAG1 sorting nexin associated golgi protein 1" .
Worby CA, Dixon JE (2003). "Sorting out the cellular functions of sorting nexins". Nat. Rev. Mol. Cell Biol . 3 (12): 919– 31. doi :10.1038/nrm974 . PMID 12461558 . S2CID 36361630 . Xu Y, Seet LF, Hanson B, Hong W (2002). "The Phox homology (PX) domain, a new player in phosphoinositide signalling" . Biochem. J . 360 (Pt 3): 513– 30. doi :10.1042/0264-6021:3600513 . PMC 1222253 PMID 11736640 . Ozyildirim AM, Wistow GJ, Gao J, et al. (2005). "The lacrimal gland transcriptome is an unusually rich source of rare and poorly characterized gene transcripts". Invest. Ophthalmol. Vis. Sci . 46 (5): 1572– 80. CiteSeerX 10.1.1.123.3574 doi :10.1167/iovs.04-1380 . PMID 15851553 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40– 5. doi :10.1038/ng1285 PMID 14702039 . Schulze WX, Mann M (2004). "A novel proteomic screen for peptide-protein interactions" . J. Biol. Chem . 279 (11): 10756– 64. doi :10.1074/jbc.M309909200 PMID 14679214 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Teasdale RD, Loci D, Houghton F, et al. (2001). "A large family of endosome-localized proteins related to sorting nexin 1" . Biochem. J . 358 (Pt 1): 7– 16. doi :10.1042/0264-6021:3580007 . PMC 1222026 PMID 11485546 .
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