1,8-Cineole 2-endo-monooxygenase
| 1,8-Cineole 2-endo-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.14.133 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
1,8-Cineole 2-endo-monooxygenase (EC 1.14.14.133, Formerly EC 1.14.13.156, P450cin, CYP176A, CYP176A1) is an enzyme with systematic name 1,8-cineole,NADPH:oxygen oxidoreductase (2-endo-hydroxylating).[1][2][3][4] This enzyme catalyses the following chemical reaction
- 1,8-cineole + NADPH + H+ + O2 2-endo-hydroxy-1,8-cineole + NADP+ + H2O
1,8-Cineole 2-endo-monooxygenase is a heme-thiolate protein (P-450).
References
[edit]- ^ Hawkes DB, Adams GW, Burlingame AL, Ortiz de Montellano PR, De Voss JJ (August 2002). "Cytochrome P450(cin) (CYP176A), isolation, expression, and characterization". The Journal of Biological Chemistry. 277 (31): 27725–32. doi:10.1074/jbc.M203382200. PMID 12016226.
- ^ Meharenna YT, Li H, Hawkes DB, Pearson AG, De Voss J, Poulos TL (July 2004). "Crystal structure of P450cin in a complex with its substrate, 1,8-cineole, a close structural homologue to D-camphor, the substrate for P450cam". Biochemistry. 43 (29): 9487–94. doi:10.1021/bi049293p. PMID 15260491.
- ^ Kimmich N, Das A, Sevrioukova I, Meharenna Y, Sligar SG, Poulos TL (September 2007). "Electron transfer between cytochrome P450cin and its FMN-containing redox partner, cindoxin". The Journal of Biological Chemistry. 282 (37): 27006–11. doi:10.1074/jbc.M703790200. PMID 17606612.
- ^ Meharenna YT, Slessor KE, Cavaignac SM, Poulos TL, De Voss JJ (April 2008). "The critical role of substrate-protein hydrogen bonding in the control of regioselective hydroxylation in p450cin". The Journal of Biological Chemistry. 283 (16): 10804–12. doi:10.1074/jbc.M709722200. PMC 2447660. PMID 18270198.
External links
[edit]- 1,8-cineole+2-endo-monooxygenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
