C7orf31

C7orf31
Identifiers
Aliases	C7orf31, chromosome 7 open reading frame 31
External IDs	OMIM: 616071; MGI: 1918071; HomoloGene: 69433; GeneCards: C7orf31; OMA:C7orf31 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	25,180,356 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	50,573,612 bp
RNA expression pattern
	Top expressed in
	sperm; ; left testis; ; right testis; ; testicle; ; gonad; ; retinal pigment epithelium; ; monocyte; ; cartilage tissue; ; left adrenal gland; ; mucosa of transverse colon;
	Top expressed in
	seminiferous tubule; ; spermatid; ; spermatocyte; ; embryo; ; embryo; ; granulocyte; ; tail of embryo; ; muscle of thigh; ; transitional epithelium of urinary bladder; ; skeletal muscle tissue;
	More reference expression data
	n/a
Orthologs
	136895
	70821
	ENSG00000153790
	ENSMUSG00000029828
	Q8N865
	Q9D5Y0
	NM_138811; NM_001371351; NM_001371352
	NM_027564
	NP_620166; NP_001358280; NP_001358281
	NP_081840
	Wikidata
View/Edit Human	View/Edit Mouse

Chromosome Seven Open Reading Frame 31 (C7orf31) is a protein that in humans is encoded by the C7orf31 gene on chromosome seven.^[5]

Gene/Locus

In humans, the C7orf31 gene is located at the locus 7p15.3 ^[5] and stretches between position 25174316 and 25219817 (span 45502 bp).^[6] It codes for at least 4 unique human isoforms: the primary isoform (590 aa; also denoted X1, X2, and CRA_c),^[7]^[8]^[9] isoform X4 (346 aa),^[10] isoform CRA_a (580 aa),^[11] and isoform CRA_b (380 aa).^[12]

Transcript

In humans, C7orf31 codes for an mRNA strand that is 3609 base pairs long. The human mRNA is composed of a 5' untranslated region that is 561 bases and a 3' untranslated region that is 1275 bases long.^[13]

Protein

The primary protein encoded by C7orf31 in humans is 590 amino acids long with molecular weight 38334 Da.^[5] The protein is part of a functionally uncharacterized family of proteins (pfam15093) with a domain of unknown function (DUF4555).^[14]

Protein Orthology

The C7orf31 protein is well-conserved in mammals and birds, but is less conserved in more distant organisms.^[15]

C7orf31 does not have any paralogs in humans.

Expression

In humans, C7orf31 is predicted to be localized in the cytosol, nucleus, mitochondrion, and peroxisome, and it is expressed in almost all tissues.^[16] It is highly expressed especially in the testes.^[17]

Interaction

Two-hybrid studies have found interactions between the proteins encoded by A8K5H9 and C7orf31,^[18] and another study has found the protein to interact with KBTBD5.^[19]

A study in 2014 found C7orf31 to be a candidate as a centrosome-associated protein, using mass spectrometry on mammalian sperm cells’ centrioles. The protein appears in the study alongside seven other centrosome-associated protein candidates.^[20] Along with 2241 other proteins, C7orf31 also exhibited significant binding in a microarray experiment to β-amyloids, a group of proteins associated with Alzheimer's disease.^[21] Finally, in a protein-protein interaction network study,^[22] C7orf31 was found to associate with KLHL40, whose exact function is also not known.^[23]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000153790 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029828 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c "NCBI Protein".
^ "UCSC Blat Results".
^ "NCBI Protein (National Center for Biotechnology Information)".
^ "NCBI Protein (National Center for Biotechnology Information)".
^ "NCBI Protein (National Center for Biotechnology Information)".
^ "NCBI Protein (National Center for Biotechnology Information)".
^ "NCBI Protein (National Center for Biotechnology Information)".
^ "NCBI Protein (National Center for Biotechnology Information)".
^ "NCBI Nucleotide (National Center for Biotechnology Information)". 11 November 2018.
^ "NCBI Conserved Domains (National Center for Biotechnology Information)".
^ "NCBI Blast (National Center for Biotechnology Information)".
^ "Genecards C7orf31".
^ "NCBI GEO (National Center for Biotechnology Information".
^ "21 binary interactions found for search term C7orf31". IntAct Molecular Interaction Database. EMBL-EBI. Retrieved 2018-08-25.
^ "STRING Database".
^ Firat-Karalar EN, Sante J, Elliott S, Stearns T (October 2014). "Proteomic analysis of mammalian sperm cells identifies new components of the centrosome". Journal of Cell Science. 127 (Pt 19): 4128–33. doi:10.1242/jcs.157008. PMC 4179487. PMID 25074808.
^ Oláh J, Vincze O, Virók D, Simon D, Bozsó Z, Tõkési N, Horváth I, Hlavanda E, Kovács J, Magyar A, Szũcs M, Orosz F, Penke B, Ovádi J (September 2011). "Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein". The Journal of Biological Chemistry. 286 (39): 34088–100. doi:10.1074/jbc.m111.243907. PMC 3190826. PMID 21832049.
^ Rolland T, Taşan M, Charloteaux B, Pevzner SJ, Zhong Q, Sahni N, et al. (November 2014). "A proteome-scale map of the human interactome network". Cell. 159 (5): 1212–1226. doi:10.1016/j.cell.2014.10.050. PMC 4266588. PMID 25416956.
^ "NCBI Gene".

External links

Human C7orf31 genome location and C7orf31 gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000153790 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029828 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[NCBI_Protein_C7orf31-5] "NCBI Protein".

[6] "UCSC Blat Results".

[7] "NCBI Protein (National Center for Biotechnology Information)".

[8] "NCBI Protein (National Center for Biotechnology Information)".

[9] "NCBI Protein (National Center for Biotechnology Information)".

[10] "NCBI Protein (National Center for Biotechnology Information)".

[11] "NCBI Protein (National Center for Biotechnology Information)".

[12] "NCBI Protein (National Center for Biotechnology Information)".

[NCBI_Nucleotide_C7orf31-13] "NCBI Nucleotide (National Center for Biotechnology Information)". 11 November 2018.

[14] "NCBI Conserved Domains (National Center for Biotechnology Information)".

[NCBI_Blast-15] "NCBI Blast (National Center for Biotechnology Information)".

[16] "Genecards C7orf31".

[17] "NCBI GEO (National Center for Biotechnology Information".

[18] "21 binary interactions found for search term C7orf31". IntAct Molecular Interaction Database. EMBL-EBI. Retrieved 2018-08-25.

[19] "STRING Database".

[20] Firat-Karalar EN, Sante J, Elliott S, Stearns T (October 2014). "Proteomic analysis of mammalian sperm cells identifies new components of the centrosome". Journal of Cell Science. 127 (Pt 19): 4128–33. doi:10.1242/jcs.157008. PMC 4179487. PMID 25074808.

[21] Oláh J, Vincze O, Virók D, Simon D, Bozsó Z, Tõkési N, Horváth I, Hlavanda E, Kovács J, Magyar A, Szũcs M, Orosz F, Penke B, Ovádi J (September 2011). "Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein". The Journal of Biological Chemistry. 286 (39): 34088–100. doi:10.1074/jbc.m111.243907. PMC 3190826. PMID 21832049.

[22] Rolland T, Taşan M, Charloteaux B, Pevzner SJ, Zhong Q, Sahni N, et al. (November 2014). "A proteome-scale map of the human interactome network". Cell. 159 (5): 1212–1226. doi:10.1016/j.cell.2014.10.050. PMC 4266588. PMID 25416956.

[23] "NCBI Gene".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]