CXCL17
| chemokine (C-X-C motif) ligand 7 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | CXCL17 | ||||||
| Alt. symbols | SCYB17, VCC-1, DMC | ||||||
| NCBI gene | 284340 | ||||||
| RefSeq | NM_198477 | ||||||
| UniProt | Q6UXB2 | ||||||
| Other data | |||||||
| Locus | Chr. 19 q13.2 | ||||||
| |||||||
Chemokine (C-X-C motif) ligand 17 (CXCL17) is a small cytokine initially thought to belong to the CXC chemokine family, then addressed as chemokine-like protein, that has been identified in humans and mice.
CXCL17 has been previously reported to attract dendritic cells and monocytes, but there are also studies not reporting this activity[1]; it is also regulated in tumors. It was formerly known as VEGF co-regulated chemokine 1 (VCC-1) and dendritic cell- and monocyte-attracting chemokine-like protein (DMC).[2][3] This chemokine is constitutively expressed in the respiratory tract and more specifically in the lung.[3] The gene for human CXCL17 is located on chromosome 19.[3] Human and murine CXCL17 protein share 71% of amino acid sequence identity [4].
Function
[edit]Being expressed in the respiratory tract mucosa, CXCL17 is likely to exert functions related to both immune surveillance of the tissue by fostering immune activation and immune suppression in case of overactivation of the immune system against harmless environmental antigens that can be commonly inhaled. CXCL17 also shows some anti-microbial activity against some bacteria, such as E.coli, S. aureus, Salmonella, P. aeruginosa and C. albicans strains.
Receptor
[edit]The receptor for CXCL17 is a G protein-coupled receptor (GPCR). The GPCR GPR35 was thought to be a receptor of CXCL17 [5] Subsequent research has suggested that GPR35 is not a receptor for CXCL17.[6][7]. Indeed, recently GPR25 has been uniquely identified as CXCL17 receptor [8]
References
[edit]- ^ Ocón, Borja; Xiang, Menglan; Bi, Yuhan; Tan, Serena; Brulois, Kevin; Ayesha, Aiman; Kunte, Manali; Zhou, Catherine; LaJevic, Melissa; Lazarus, Nicole; Mengoni, Francesca; Sharma, Tanya; Montgomery, Stephen; Hooper, Jody E.; Huang, Mian; Handel, Tracy; Dawson, John R. D.; Kufareva, Irina; Zabel, Brian A.; Pan, Junliang; Butcher, Eugene C. (21 November 2024). "A lymphocyte chemoaffinity axis for lung, non-intestinal mucosae and CNS". Nature. 635 (8039): 736–745. doi:10.1038/s41586-024-08043-2. PMC 11887596.
- ^ Weinstein EJ, Head R, Griggs DW, Sun D, Evans RJ, Swearingen ML, Westlin MM, Mazzarella R (November 2006). "VCC-1, a novel chemokine, promotes tumor growth". Biochemical and Biophysical Research Communications. 350 (1): 74–81. doi:10.1016/j.bbrc.2006.08.194. PMID 16989774.
- ^ a b c Pisabarro MT, Leung B, Kwong M, Corpuz R, Frantz GD, Chiang N, Vandlen R, Diehl LJ, Skelton N, Kim HS, Eaton D, Schmidt KN (February 2006). "Cutting edge: novel human dendritic cell- and monocyte-attracting chemokine-like protein identified by fold recognition methods". Journal of Immunology. 176 (4): 2069–73. doi:10.4049/jimmunol.176.4.2069. PMID 16455961.
- ^ Choreño-Parra, José Alberto; Thirunavukkarasu, Shyamala; Zúñiga, Joaquín; Khader, Shabaana A. (June 2020). "The protective and pathogenic roles of CXCL17 in human health and disease: Potential in respiratory medicine". Cytokine & Growth Factor Reviews. 53: 53–62. doi:10.1016/j.cytogfr.2020.04.004. PMC 7177079.
- ^ Maravillas-Montero JL, Burkhardt AM, Hevezi PA, Carnevale CD, Smit MJ, Zlotnik A (January 2015). "Cutting edge: GPR35/CXCR8 is the receptor of the mucosal chemokine CXCL17". Journal of Immunology. 194 (1): 29–33. doi:10.4049/jimmunol.1401704. PMC 4355404. PMID 25411203.
- ^ Binti Mohd Amir NA, Mackenzie AE, Jenkins L, Boustani K, Hillier MC, Tsuchiya T, Milligan G, Pease JE (June 2018). "Evidence for the Existence of a CXCL17 Receptor Distinct from GPR35". Journal of Immunology. 201 (2): 714–724. doi:10.4049/jimmunol.1700884. PMC 6036231. PMID 29875152.
- ^ Park SJ, Lee SJ, Nam SY, Im DS (January 2018). "GPR35 mediates lodoxamide-induced migration inhibitory response but not CXCL17-induced migration stimulatory response in THP-1 cells; is GPR35 a receptor for CXCL17?". British Journal of Pharmacology. 175 (1): 154–161. doi:10.1111/bph.14082. PMC 5740256. PMID 29068046.
- ^ Ocón, Borja; Xiang, Menglan; Bi, Yuhan; Tan, Serena; Brulois, Kevin; Ayesha, Aiman; Kunte, Manali; Zhou, Catherine; LaJevic, Melissa; Lazarus, Nicole; Mengoni, Francesca; Sharma, Tanya; Montgomery, Stephen; Hooper, Jody E.; Huang, Mian; Handel, Tracy; Dawson, John R. D.; Kufareva, Irina; Zabel, Brian A.; Pan, Junliang; Butcher, Eugene C. (21 November 2024). "A lymphocyte chemoaffinity axis for lung, non-intestinal mucosae and CNS". Nature. 635 (8039): 736–745. doi:10.1038/s41586-024-08043-2. PMC 11887596.
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