GPR120 compound A

GPR120 compound A
Identifiers
	IUPAC name 2-[3-[2-chloro-5-(trifluoromethoxy)phenyl]-3-azaspiro[5.5]undecan-9-yl]acetic acid;
CAS Number	1599477-75-4;
PubChem CID	73777063;
IUPHAR/BPS	8418;
ChemSpider	35033244;
ChEMBL	ChEMBL3919973;
Chemical and physical data
Formula	C19H23ClF3NO3
Molar mass	405.84 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CC2(CCC1CC(=O)O)CCN(CC2)C3=C(C=CC(=C3)OC(F)(F)F)Cl;
	InChI InChI=1S/C19H23ClF3NO3/c20-15-2-1-14(27-19(21,22)23)12-16(15)24-9-7-18(8-10-24)5-3-13(4-6-18)11-17(25)26/h1-2,12-13H,3-11H2,(H,25,26); Key:WUJVPELCYCESAP-UHFFFAOYSA-N;

GPR120 compound A is an experimental drug which acts as a potent and highly selective agonist for the free fatty acid receptor FFAR4 (GPR120). It has antiinflammatory effects and regulates glucose homeostasis and insulin release. It has been researched in animal models of diabetes. GPR120 compound A has also been referred to as GPR120 agonist III but this has also been used in some papers to refer to the older compound TUG-891, which may cause confusion about which drug was used if the chemical structure or other unique identifiers are not specifically stated.^[1]^[2]^[3]

References

^ Oh DY, Walenta E, Akiyama TE, Lagakos WS, Lackey D, Pessentheiner AR, et al. (August 2014). "A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice". Nature Medicine. 20 (8): 942–947. doi:10.1038/nm.3614. PMC 4126875. PMID 24997608.
^ Cox JM, Chu HD, Chelliah MV, Debenham JS, Eagen K, Lan P, et al. (January 2017). "Design, Synthesis, and Evaluation of Novel and Selective G-protein Coupled Receptor 120 (GPR120) Spirocyclic Agonists". ACS Medicinal Chemistry Letters. 8 (1): 49–54. doi:10.1021/acsmedchemlett.6b00360. PMC 5238469. PMID 28105274.
^ Son SE, Park SJ, Koh JM, Im DS (October 2020). "Free fatty acid receptor 4 (FFA4) activation ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis by increasing regulatory T cells in mice". Acta Pharmacologica Sinica. 41 (10): 1337–1347. doi:10.1038/s41401-020-0435-1. PMC 7609340. PMID 32555509.

[1] Oh DY, Walenta E, Akiyama TE, Lagakos WS, Lackey D, Pessentheiner AR, et al. (August 2014). "A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice". Nature Medicine. 20 (8): 942–947. doi:10.1038/nm.3614. PMC 4126875. PMID 24997608.

[2] Cox JM, Chu HD, Chelliah MV, Debenham JS, Eagen K, Lan P, et al. (January 2017). "Design, Synthesis, and Evaluation of Novel and Selective G-protein Coupled Receptor 120 (GPR120) Spirocyclic Agonists". ACS Medicinal Chemistry Letters. 8 (1): 49–54. doi:10.1021/acsmedchemlett.6b00360. PMC 5238469. PMID 28105274.

[3] Son SE, Park SJ, Koh JM, Im DS (October 2020). "Free fatty acid receptor 4 (FFA4) activation ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis by increasing regulatory T cells in mice". Acta Pharmacologica Sinica. 41 (10): 1337–1347. doi:10.1038/s41401-020-0435-1. PMC 7609340. PMID 32555509.

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