Linvoseltamab
| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Human |
| Target | CD3 and BCMA |
| Clinical data | |
| Trade names | Lynozyfic |
| Other names | REGN5458, REGN-5458 |
| ATC code |
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| Legal status | |
| Legal status | |
| Identifiers | |
| CAS Number | |
| DrugBank | |
| UNII | |
| KEGG | |
| Chemical and physical data | |
| Formula | C6455H9955N1721O2039S47 |
| Molar mass | 145800.47 g·mol−1 |
Linvoseltamab, sold under the brand name Lynozyfic, is an anti-cancer medication used for the treatment of people with relapsed and refractory multiple myeloma.[1][3] Linvoseltamab is a bispecific monoclonal antibody that targets CD3 and BCMA (TNFRSF17).[1]
Lynozyfic was authorized for medical use in the European Union in April 2025.[1][2]
Medical uses
[edit]Linvoseltamab is indicated as monotherapy for the treatment of adult patients with relapsed and refractory multiple myeloma who have received at least three prior therapies, including a proteasome inhibitor, an immunomodulatory agent, and an anti CD38 monoclonal antibody, and have demonstrated disease progression on the last therapy.[1]
Society and culture
[edit]Legal status
[edit]In February 2025, the Committee for Medicinal Products for Human Use of the European Medicines Agency adopted a positive opinion, recommending the granting of a conditional marketing authorization for the medicinal product Lynozyfic, intended for the treatment of people with relapsed and refractory multiple myeloma who have received at least three prior therapies.[1] The applicant for this medicinal product is Regeneron Ireland DAC.[1] Lynozyfic was authorized for medical use in the European Union in April 2025.[2]
Names
[edit]Linvoseltamab is the international nonproprietary name.[4]
References
[edit]- ^ a b c d e f g "Lynozyfic EPAR". European Medicines Agency (EMA). 27 February 2025. Retrieved 6 March 2025. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
- ^ a b c "Lynozyfic PI". Union Register of medicinal products. 25 April 2025. Retrieved 3 May 2025.
- ^ Avigan ZM, Rattu MA, Richter J (February 2025). "An evaluation of linvoseltamab for treatment of relapsed/refractory multiple myeloma". Expert Opinion on Biological Therapy. 25 (3): 221–228. doi:10.1080/14712598.2025.2465825. PMID 39923122.
- ^ World Health Organization (2022). "International nonproprietary names for pharmaceutical substances (INN): recommended INN: list 88". WHO Drug Information. 36 (3). hdl:10665/363551.
External links
[edit]- "Linvoseltamab (Code C158504)". NCI Thesaurus.
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