Mir-633 microRNA precursor family
| mir-633 | |
|---|---|
| Identifiers | |
| Symbol | mir-633 |
| Rfam | RF01028 |
| miRBase family | MIPF0000546 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota; |
| PDB structures | PDBe |
In molecular biology mir-633 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
miR-633 in Leukaemia
[edit]miR-633 has been linked to acute lymphoblastic leukaemia (ALL) and as having a potential role in the development of leukaemia, due to abnormal expression in ALL subjects.[1] It may be of use for prediction of relapse potential and in development of personalised leukaemia treatments.
Progesterone regulation
[edit]miR-633 expression in endometrial carcinoma cells upon treatment with progesterone saw a 50% decrease in expression levels. These point towards a possible critical role of miR-633, alongside other miRNAs, in the regulation of posttranscriptional gene expression on progesterone treatment.[2]
See also
[edit]References
[edit]- ^ Xu L, Liang YN, Luo XQ, Liu XD, Guo HX (2011). "[Association of miRNAs expression profiles with prognosis and relapse in childhood acute lymphoblastic leukemia]". Zhonghua Xue Ye Xue Za Zhi. 32 (3): 178–81. PMID 21535956.
- ^ Bae J, Won M, Kim DY, Kim JH, Kim YM, Kim YT, et al. (2012). "Identification of differentially expressed microRNAs in endometrial cancer cells after progesterone treatment". Int J Gynecol Cancer. 22 (4): 561–5. doi:10.1097/IGC.0b013e31824927db. PMID 22543862. S2CID 205679152.
External links
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