Zinc transporter ZIP6

SLC39A6
Identifiers
Aliases	SLC39A6, LIV-1, ZIP6, solute carrier family 39 member 6, LIV1
External IDs	OMIM: 608731; MGI: 2147279; HomoloGene: 8199; GeneCards: SLC39A6; OMA:SLC39A6 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	36,129,385 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	24,736,874 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; Epithelium of choroid plexus; ; retinal pigment epithelium; ; hair follicle; ; tibia; ; seminal vesicula; ; gingival epithelium; ; caput epididymis; ; epithelium of lactiferous gland; ; lactiferous duct;
	Top expressed in
	hair follicle; ; superior cervical ganglion; ; saccule; ; primary oocyte; ; supraoptic nucleus; ; condyle; ; decidua; ; molar; ; otic vesicle; ; zygote;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	metal ion transmembrane transporter activity; zinc ion transmembrane transporter activity;
Cellular component	integral component of membrane; cell surface; plasma membrane; integral component of plasma membrane; lamellipodium membrane; endoplasmic reticulum; membrane;
Biological process	metal ion transport; zinc ion transmembrane transport; zinc ion transport; zinc ion import across plasma membrane; ion transport; cellular zinc ion homeostasis; transmembrane transport; transport;
	Sources:Amigo / QuickGO
Orthologs
	25800
	106957
	ENSG00000141424
	ENSMUSG00000024270
	Q13433
	Q8C145
	NM_001099406; NM_012319
	NM_139143
	NP_001092876; NP_036451
	NP_631882
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc transporter ZIP6 is a protein that in humans is encoded by the SLC39A6 gene.^[5]^[6]^[7]

Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A6 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003).[supplied by OMIM]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000141424 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024270 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Taylor KM, Nicholson RI (Mar 2003). "The LZT proteins; the LIV-1 subfamily of zinc transporters". Biochim Biophys Acta. 1611 (1–2): 16–30. doi:10.1016/S0005-2736(03)00048-8. PMID 12659941.
^ Taylor KM, Morgan HE, Johnson A, Hadley LJ, Nicholson RI (Sep 2003). "Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters". Biochem J. 375 (Pt 1): 51–9. doi:10.1042/BJ20030478. PMC 1223660. PMID 12839489.
^ ^a ^b "Entrez Gene: SLC39A6 solute carrier family 39 (zinc transporter), member 6".

Manning DL, Daly RJ, Lord PG, et al. (1988). "Effects of oestrogen on the expression of a 4.4 kb mRNA in the ZR-75-1 human breast cancer cell line". Mol. Cell. Endocrinol. 59 (3): 205–12. doi:10.1016/0303-7207(88)90105-0. PMID 2903103. S2CID 23701658.
Dressman MA, Walz TM, Lavedan C, et al. (2002). "Genes that co-cluster with estrogen receptor alpha in microarray analysis of breast biopsies". Pharmacogenomics J. 1 (2): 135–41. doi:10.1038/sj.tpj.6500022. PMID 11911440.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Schaner ME, Ross DT, Ciaravino G, et al. (2004). "Gene expression patterns in ovarian carcinomas". Mol. Biol. Cell. 14 (11): 4376–86. doi:10.1091/mbc.E03-05-0279. PMC 266758. PMID 12960427.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kasper G, Weiser AA, Rump A, et al. (2005). "Expression levels of the putative zinc transporter LIV-1 are associated with a better outcome of breast cancer patients". Int. J. Cancer. 117 (6): 961–73. doi:10.1002/ijc.21235. PMID 15986450. S2CID 43808796.
Zhao L, Chen W, Taylor KM, et al. (2007). "LIV-1 suppression inhibits HeLa cell invasion by targeting ERK1/2-Snail/Slug pathway". Biochem. Biophys. Res. Commun. 363 (1): 82–8. doi:10.1016/j.bbrc.2007.08.127. PMID 17825787.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000141424 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024270 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12659941-5] Taylor KM, Nicholson RI (Mar 2003). "The LZT proteins; the LIV-1 subfamily of zinc transporters". Biochim Biophys Acta. 1611 (1–2): 16–30. doi:10.1016/S0005-2736(03)00048-8. PMID 12659941.

[pmid12839489-6] Taylor KM, Morgan HE, Johnson A, Hadley LJ, Nicholson RI (Sep 2003). "Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters". Biochem J. 375 (Pt 1): 51–9. doi:10.1042/BJ20030478. PMC 1223660. PMID 12839489.

[entrez-7] "Entrez Gene: SLC39A6 solute carrier family 39 (zinc transporter), member 6".

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Zinc transporter ZIP6

See also

References

Further reading