Supralingual administration
Supralingual, from the Latin for "above the tongue" (supra + lingual), refers to the pharmacological route of administration by which substances diffuse into the blood through tissues above the tongue.[1][2][3]It is often the route of administration of choice when one would like the drug to bypass or alleviate the first-pass effect on the drug after oral delivery.[3]
See also
[edit]References
[edit]- ^ Panzner, Petr; Petráš, Mark; Sýkora, Tomáš; Lesná, Ivana Králová; Liška, Martin (2011). "Both sublingual and supralingual routes of administration are effective in long-term allergen-specific immunotherapy". Allergy and Asthma Proceedings. 32 (2): 142–150. doi:10.2500/aap.2011.32.3423. ISSN 1539-6304. PMID 21439167. Retrieved 2025-06-20.
- ^ Loprete, Luca; Leuratti, Chiara; Frangione, Valeria; Radicioni, Milko (2018). "Pharmacokinetics of a Novel Sildenafil Orodispersible Film Administered by the Supralingual and the Sublingual Route to Healthy Men" (PDF). Clinical Drug Investigation. 38 (8): 765–772. doi:10.1007/s40261-018-0665-x. ISSN 1173-2563. PMC 6061399. PMID 29909432. Retrieved 2025-06-20.
- ^ a b Bartlett, Jeremy A.; van der Voort Maarschalk, Kees (2012). "Understanding the oral mucosal absorption and resulting clinical pharmacokinetics of asenapine". AAPS PharmSciTech. 13 (4): 1110–1115. doi:10.1208/s12249-012-9839-7. ISSN 1530-9932. PMC 3513449. PMID 22936407.
Oral mucosal (e.g. sub- or supralingual or buccal) administration of drugs is often the route of administration of choice when the drug shows a large first-pass effect after oral delivery.
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