TAS2R14 agonist 28.1

TAS2R14 agonist 28.1
Identifiers
	IUPAC name 4-methyl-N-[2-(2H-tetrazol-5-yl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine;
CAS Number	2883007-69-8;
PubChem CID	167312460;
ChemSpider	129308500;
ChEMBL	ChEMBL5279691;
Chemical and physical data
Formula	C13H10F3N7
Molar mass	321.267 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=CC(=NC(=N1)NC2=CC=CC=C2C3=NNN=N3)C(F)(F)F;
	InChI InChI=1S/C13H10F3N7/c1-7-6-10(13(14,15)16)19-12(17-7)18-9-5-3-2-4-8(9)11-20-22-23-21-11/h2-6H,1H3,(H,17,18,19)(H,20,21,22,23); Key:XXKGCSWBGJTTJM-UHFFFAOYSA-N;

TAS2R14 agonist 28.1 (sometimes referred to simply as 28.1) is an experimental drug that acts as a potent and selective agonist of the bitter taste receptor TAS2R14. It was developed by modification of flufenamic acid, a pharmaceutical known for its bitter taste which produces bitterness via activation of TAS2R14, but is around six times more potent. TAS2R14 is also expressed in the lungs and causes bronchodilatation, so TAS2R14 agonists such as 28.1 may be useful in the treatment of asthma and other lung diseases.^[1]

References

^ Waterloo L, Hübner H, Fierro F, Pfeiffer T, Brox R, Löber S, et al. (March 2023). "Discovery of 2-Aminopyrimidines as Potent Agonists for the Bitter Taste Receptor TAS2R14". Journal of Medicinal Chemistry. 66 (5): 3499–3521. doi:10.1021/acs.jmedchem.2c01997. PMID 36847646.

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[1] Waterloo L, Hübner H, Fierro F, Pfeiffer T, Brox R, Löber S, et al. (March 2023). "Discovery of 2-Aminopyrimidines as Potent Agonists for the Bitter Taste Receptor TAS2R14". Journal of Medicinal Chemistry. 66 (5): 3499–3521. doi:10.1021/acs.jmedchem.2c01997. PMID 36847646.

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See also

References