Template:Plasma levels and binding potential of flutamide and bicalutamide during first week

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Plasma levels and binding potential of flutamide and bicalutamide during first week
Day	Total levels (ng/mL)		Free levels (ng/mL)		Ratios
Day	Bicalutamide	Flutamide^a	Bicalutamide	Flutamide^a	Free	Binding potential^b
1	901	940	36.0	66	0.55	2.18
2	1613	1500	64.5	105	0.61	2.46
3	2345	1500	93.8	105	0.89	3.57
4	2969	1500	118.8	105	1.13	4.53
7	4259	1500	170.4	105	1.62	6.49
Notes: During first week of treatment. Dosages not provided. Footnotes: ^a = As 2-hydroxyflutamide (the active form of flutamide). ^b = Assumes, on the basis of ligand binding assays, that bicalutamide possesses 4-fold greater affinity for the androgen receptor than 2-hydroxyflutamide. Sources: ^[1]

References

^ Blackledge GR (1996). "Clinical progress with a new antiandrogen, Casodex (bicalutamide)". Eur. Urol. 29 Suppl 2: 96–104. doi:10.1159/000473847. PMID 8717470.