User:Jared BioE
Currently working on:
[edit]- Researching for updates to NINJ1.
- Creating a page for FWE: User:Jared BioE/sandbox
Gene pages that could use a little love
[edit]Here is a checklist of different genes and proteins that I want to work on, so I don't forget.
| Gene Name | Full Name | Why it needs some love | Resources |
|---|---|---|---|
| NINJ1 | Ninjurin 1 | Article is a stub, but gene has a well characterized role in mediating plasma membrane rupture. | Pourmal, S., Truong, M.E., Johnson, M.C. et al. Autoinhibition of dimeric NINJ1 prevents plasma membrane rupture. Nature (2024). https://doi.org/10.1038/s41586-024-08273-4
NINJ1 protein expression summary - The Human Protein Atlas |
| FWE | Flower | hFWE isforms are transmembrane proteins involved in cell-cell competition. Article does not exist yet, despite interesting function and several research articles. | https://doi.org/10.1016/j.jbc.2023.104945
Madan E, Pelham CJ, Nagane M, et al. Flower isoforms promote competitive growth in cancer. Nature. 2019;572(7768):260-264. doi:10.1038/s41586-019-1429-3 Ferrari AJ, Drapkin R, Gogna R. Cell Fitness: More Than Push-Ups. Int J Mol Sci. 2021;22(2):518. Published 2021 Jan 7. doi:10.3390/ijms22020518 |
| STK19 | Serine threonine kinase 19 (not actually a kinase though) | Recently identified involved in transcription-coupled nucleotide excision repair. | Mevissen TET, Kümmecke M, Schmid EW, Farnung L, Walter JC. STK19 positions TFIIH for cell-free transcription-coupled DNA repair. Cell. Published online November 12, 2024. doi:10.1016/j.cell.2024.10.020 |
| CD19ORF84 | unnamed | Article does not exist. Article in Molecular Cell shows it interacts with SPOCD1 and is essential for piRNA-directed transposon methylation. | Zoch A, Konieczny G, Auchynnikava T, et al. C19ORF84 connects piRNA and DNA methylation machineries to defend the mammalian germ line. Mol Cell. 2024;84(6):1021-1035.e11. doi:10.1016/j.molcel.2024.01.014 |
| CCAR1 | Cell division cycle and apoptosis regulator protein 1 | This gene is involved in DNA repair, but is still a stub. | Harada N, Asada S, Jiang L, et al. The splicing factor CCAR1 regulates the Fanconi anemia/BRCA pathway. Mol Cell. 2024;84(14):2618-2633.e10. doi:10.1016/j.molcel.2024.06.031
Karasu ME, Jahnke L, Joseph BJ, et al. CCAR1 promotes DNA repair via alternative splicing. Mol Cell. 2024;84(14):2634-2647.e9. doi:10.1016/j.molcel.2024.06.011 Ai Y, Abdel-Wahab O. Splicing regulation of DNA repair via CCAR1. Mol Cell. 2024;84(14):2591-2592. doi:10.1016/j.molcel.2024.06.012 |
| PRDX6 | Peroxiredoxin6 | Add more information related to contribution to selenocysteine metabolism and ferroptosis. | Ito J, Nakamura T, Toyama T, et al. PRDX6 dictates ferroptosis sensitivity by directing cellular selenium utilization. Mol Cell. 2024;84(23):4629-4644.e9. doi:10.1016/j.molcel.2024.10.028
Chen Z, Inague A, Kaushal K, et al. PRDX6 contributes to selenocysteine metabolism and ferroptosis resistance. Mol Cell. 2024;84(23):4645-4659.e9. doi:10.1016/j.molcel.2024.10.027 |
| MORC3 | MORC family CW-type zinc finger protein 3 | MORC3 has antiviral activity and is also a repressor or INFB1. | Fox LE, Lenschow DJ. En garde! The duel functions of MORC3. Cell Host Microbe. 2022;30(1):8-9. doi:10.1016/j.chom.2021.12.017 |
| ABCB4 | ATP-binding cassette 4 | Could use an update and expansion. | https://www.proteinatlas.org/ENSG00000005471-ABCB4 |
| Let-7 | lethal 7 miRNA | Found some excellent images showing pri-let-7 processing. Could pull these off of PDB and add to the page? | Garg A, Shang R, Cvetanovic T, Lai EC, Joshua-Tor L. The structural landscape of Microprocessor-mediated processing of pri-let-7 miRNAs. Mol Cell. 2024 Nov 7;84(21):4175-4190.e6. doi: 10.1016/j.molcel.2024.09.008. Epub 2024 Oct 4. PMID: 39368465; PMCID: PMC11560618. https://doi.org/10.1016/j.molcel.2024.09.008 |
| ARHGAP36 | Rho GTPase activating protein 36 | Article does not exist. | Equivalent in cats is responsible for X-linked Orange Coat coloration : https://theconversation.com/ginger-tortie-calico-the-mystery-gene-responsible-for-orange-colour-in-cat-coats-has-been-found-244934 |
Articles Wikipedia Could Use
[edit]- 5-ethynyl uridine (EU), which is used to detect global RNA transcription, needs an article.
- The FirstLook Test for lung cancer is a liquid biopsy test for lung cancer based on fragmentomics doesn't have an article. FirstLook Blood Test
- For that matter, fragmentomics (study of fragmentation profiles of cell free DNA) also needs an article.
- The pesticide Calantha marketed by GreenLight Biosciences for use in the Colorado Potato Bettle is the first pesticide based on RNA interference (RNAi) and promises a more precise way to target insects with less cross-species toxicity. Science named it as a runner up to their 2024 Breakthrough of the Year.
- Could maybe use an article summarizing different RNA decay pathways, some of which don't seem to have any articles. Possible source: doi:10.1016/j.tcb.2023.11.003
Protein Complexes Pages that Could use Some Love
[edit]- The MHC I Peptide Loading Complex has a beautiful new diagram over at PDB, which could be used to update this page. [1]
Gems
[edit]Fascinating things I found on wikipedia.
- The great encyclopedist Diderot rants about stubs. "Aguaxima, a plant growing in Brazil and on the islands of South America. This is all that we are told about it; and I would like to know for whom such descriptions are made...." Read his comments in all their magnificence, then check out the userpage of MtBotany, where I first saw it mentioned.