2-deoxy-D-gluconate 3-dehydrogenase
| 2-deoxy-D-gluconate 3-dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.125 | ||||||||
| CAS no. | 37250-54-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
2-deoxy-D-gluconate 3-dehydrogenase (EC 1.1.1.125) is an enzyme that catalyzes the chemical reaction
- 2-deoxy-D-gluconate + NAD+ 3-dehydro-2-deoxy-D-gluconate + NADH + H+
Thus, the two substrates of this enzyme are 2-deoxy-D-gluconate and NAD+, whereas its 3 products are 3-dehydro-2-deoxy-D-gluconate, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-deoxy-D-gluconate:NAD+ 3-oxidoreductase. This enzyme is also called 2-deoxygluconate dehydrogenase. This enzyme participates in pentose and glucuronate interconversions.
Structural studies
[edit]As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1X1E.
References
[edit]- Eichhorn MM, Cynkin MA (January 1965). "Microbial metabolism of 2-deoxyglucose; 2-deoxyglucose acid dehydrogenase". Biochemistry. 4: 159–65. doi:10.1021/bi00877a024. PMID 14285233.
