List of EC numbers (EC 1)

This list contains a list of EC numbers for the first group, EC 1, oxidoreductases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology. All official information is tabulated at the website of the committee.^[1] The database is developed and maintained by Andrew McDonald.^[2]

EC 1.1 Acting on the CH-OH group of donors

EC 1.1.4 With a disulfide as acceptor

EC 1.1.4.1: Now EC 1.17.4.4, vitamin-K-epoxide reductase (warfarin-sensitive)
EC 1.1.4.2: Now EC 1.17.4.5, vitamin-K-epoxide reductase (warfarin-insensitive)

EC 1.1.5 With a quinone or similar compound as acceptor

EC 1.1.5.1: deleted, see EC 1.1.99.18 cellobiose dehydrogenase (acceptor)
EC 1.1.5.2: quinoprotein glucose dehydrogenase
EC 1.1.5.3: glycerol-3-phosphate dehydrogenase (quinone)
EC 1.1.5.4: malate dehydrogenase (quinone)
EC 1.1.5.5: alcohol dehydrogenase (quinone)
EC 1.1.5.6: formate dehydrogenase-N
EC 1.1.5.7: cyclic alcohol dehydrogenase (quinone)
EC 1.1.5.8: quinate dehydrogenase (quinone)

EC 1.1.9 With a copper protein as acceptor

EC 1.1.9.1: alcohol dehydrogenase (azurin)

EC 1.1.98 With other, known, acceptors

EC 1.1.98.1: Now EC 1.1.9.1, alcohol dehydrogenase (azurin)
EC 1.1.98.2: glucose-6-phosphate dehydrogenase (coenzyme-F₄₂₀)
EC 1.1.98.3: decaprenylphospho-β-D-ribofuranose 2-oxidase
EC 1.1.98.3: decaprenylphospho-β-D-ribofuranose 2-dehydrogenase
EC 1.1.98.4: F₄₂₀H₂:quinone oxidoreductase
EC 1.1.98.5: secondary-alcohol dehydrogenase (coenzyme-F₄₂₀)
EC 1.1.98.6: ribonucleoside-triphosphate reductase (formate)
EC 1.1.98.7: serine-type anaerobic sulfatase-maturating enzyme

EC 1.1.99 With unknown physiological acceptors

EC 1.1.99.1: choline dehydrogenase
EC 1.1.99.2: L-2-hydroxyglutarate dehydrogenase
EC 1.1.99.3: gluconate 2-dehydrogenase (acceptor)
EC 1.1.99.4: dehydrogluconate dehydrogenase
EC 1.1.99.5: now EC 1.1.5.3, glycerol-3-phosphate dehydrogenase
EC 1.1.99.6: D-2-hydroxy-acid dehydrogenase
EC 1.1.99.7: lactate—malate transhydrogenase
EC 1.1.99.8: Now EC 1.1.2.7, methanol dehydrogenase (cytochrome c) and EC 1.1.2.8, alcohol dehydrogenase (cytochrome c).
EC 1.1.99.9: pyridoxine 5-dehydrogenase
EC 1.1.99.10: Now EC 1.1.5.9, glucose 1-dehydrogenase (FAD, quinone)
EC 1.1.99.11: Now classified as EC 1.1.5.14, fructose 5-dehydrogenase
EC 1.1.99.12: sorbose dehydrogenase
EC 1.1.99.13: glucoside 3-dehydrogenase
EC 1.1.99.14: glycolate dehydrogenase
EC 1.1.99.15: Now EC 1.5.1.20, methylenetetrahydrofolate reductase [NAD(P)H]
EC 1.1.99.16: Now EC EC 1.1.5.4, malate dehydrogenase (quinone)
EC 1.1.99.17: Now EC 1.1.5.2, quinoprotein glucose dehydrogenase
EC 1.1.99.18: cellobiose dehydrogenase (acceptor)
EC 1.1.99.19: Now EC 1.17.99.4, uracil/thymine dehydrogenase
EC 1.1.99.20: alkan-1-ol dehydrogenase (acceptor)
EC 1.1.99.21: D-sorbitol dehydrogenase (acceptor)
EC 1.1.99.22: glycerol dehydrogenase (acceptor)
EC 1.1.99.23: Now EC 1.1.2.6, polyvinyl alcohol dehydrogenase (cytochrome)
EC 1.1.99.24: hydroxyacid-oxoacid transhydrogenase
EC 1.1.99.25: Now EC 1.1.5.8, quinate dehydrogenase (quinone),
EC 1.1.99.26: 3-hydroxycyclohexanone dehydrogenase
EC 1.1.99.27: (R)-pantolactone dehydrogenase (flavin)
EC 1.1.99.28: glucose-fructose oxidoreductase
EC 1.1.99.29: pyranose dehydrogenase (acceptor)
EC 1.1.99.30: 2-oxoacid reductase
EC 1.1.99.31: (S)-mandelate dehydrogenase
EC 1.1.99.32: L-sorbose 1-dehydrogenase
EC 1.1.99.33: Now EC 1.17.99.7, formate dehydrogenase (acceptor)
EC 1.1.99.34: now EC 1.1.98.2, glucose-6-phosphate dehydrogenase (coenzyme-F₄₂₀)
EC 1.1.99.35: soluble quinoprotein glucose dehydrogenase
EC 1.1.99.36: alcohol dehydrogenase (nicotinoprotein)
EC 1.1.99.37: methanol dehydrogenase (nicotinoprotein)
EC 1.1.99.38: 2-deoxy-scyllo-inosamine dehydrogenase (AdoMet-dependent)
EC 1.1.99.39: D-2-hydroxyglutarate dehydrogenase
EC 1.1.99.40: (R)-2-hydroxyglutarate—pyruvate transhydrogenase
EC 1.1.99.41: 3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine reductase
EC 1.1.99.42: 4-pyridoxic acid dehydrogenase

EC 1.2 Acting on the aldehyde or oxo group of donors

EC 1.2.1 With NAD⁺ or NADP⁺ as acceptor

EC 1.2.1.1: deleted, replaced by EC 1.1.1.284, S-(hydroxymethyl)glutathione dehydrogenase and EC 4.4.1.22, S-(hydroxymethyl)glutathione synthase
EC 1.2.1.2: Now EC 1.17.1.9, formate dehydrogenase
EC 1.2.1.3: aldehyde dehydrogenase (NAD⁺)
EC 1.2.1.4: aldehyde dehydrogenase (NADP⁺)
EC 1.2.1.5: aldehyde dehydrogenase (NAD(P)⁺)
EC 1.2.1.6: deleted (was benzaldehyde dehydrogenase)
EC 1.2.1.7: benzaldehyde dehydrogenase (NADP⁺)
EC 1.2.1.8: betaine-aldehyde dehydrogenase
EC 1.2.1.9: glyceraldehyde-3-phosphate dehydrogenase (NADP⁺)
EC 1.2.1.10: acetaldehyde dehydrogenase (acetylating)
EC 1.2.1.11: aspartate-semialdehyde dehydrogenase
EC 1.2.1.12: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)
EC 1.2.1.13: glyceraldehyde-3-phosphate dehydrogenase (NADP⁺) (phosphorylating)
EC 1.2.1.14: Now EC 1.1.1.205, IMP dehydrogenase
EC 1.2.1.15: malonate-semialdehyde dehydrogenase
EC 1.2.1.16: succinate-semialdehyde dehydrogenase [NAD(P)⁺]
EC 1.2.1.17: glyoxylate dehydrogenase (acylating)
EC 1.2.1.18: malonate-semialdehyde dehydrogenase (acetylating)
EC 1.2.1.19: aminobutyraldehyde dehydrogenase
EC 1.2.1.20: glutarate-semialdehyde dehydrogenase
EC 1.2.1.21: glycolaldehyde dehydrogenase
EC 1.2.1.22: lactaldehyde dehydrogenase
EC 1.2.1.23: 2-oxoaldehyde dehydrogenase (NAD⁺)
EC 1.2.1.24: succinate-semialdehyde dehydrogenase (NAD⁺)
EC 1.2.1.25: branched-chain α-keto acid dehydrogenase system
EC 1.2.1.26: 2,5-dioxovalerate dehydrogenase
EC 1.2.1.27: methylmalonate-semialdehyde dehydrogenase (CoA-acylating)
EC 1.2.1.28: benzaldehyde dehydrogenase (NAD⁺)
EC 1.2.1.29: aryl-aldehyde dehydrogenase
EC 1.2.1.30: carboxylate reductase (NADP⁺)
EC 1.2.1.31: L-aminoadipate-semialdehyde dehydrogenase
EC 1.2.1.32: aminomuconate-semialdehyde dehydrogenase
EC 1.2.1.33: (R)-dehydropantoate dehydrogenase
EC 1.2.1.34: Now EC 1.1.1.131, mannuronate reductase
EC 1.2.1.35: Now EC 1.1.1.203, uronate dehydrogenase
EC 1.2.1.36: retinal dehydrogenase
EC 1.2.1.37: Now EC 1.17.1.4, xanthine dehydrogenase
EC 1.2.1.38: N-acetyl-γ-glutamyl-phosphate reductase
EC 1.2.1.39: phenylacetaldehyde dehydrogenase
EC 1.2.1.40: part of EC 1.14.13.15, cholestanetriol 26-monooxygenase
EC 1.2.1.41: glutamate-5-semialdehyde dehydrogenase
EC 1.2.1.42: hexadecanal dehydrogenase (acylating)
EC 1.2.1.43: Now EC 1.17.1.10, formate dehydrogenase (NADP⁺)
EC 1.2.1.44: cinnamoyl-CoA reductase
EC 1.2.1.45: Now EC 1.1.1.312, 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase
EC 1.2.1.46: formaldehyde dehydrogenase
EC 1.2.1.47: 4-trimethylammoniobutyraldehyde dehydrogenase
EC 1.2.1.48: long-chain-aldehyde dehydrogenase
EC 1.2.1.49: 2-oxoaldehyde dehydrogenase (NADP⁺)
EC 1.2.1.50: long-chain-fatty-acyl-CoA reductase
EC 1.2.1.51: pyruvate dehydrogenase (NADP⁺)
EC 1.2.1.52: oxoglutarate dehydrogenase (NADP⁺)
EC 1.2.1.53: 4-hydroxyphenylacetaldehyde dehydrogenase
EC 1.2.1.54: γ-guanidinobutyraldehyde dehydrogenase
EC 1.2.1.55: Now EC 1.1.1.279, (R)-3-hydroxyacid-ester dehydrogenase
EC 1.2.1.56: Now EC 1.1.1.280, (S)-3-hydroxyacid-ester dehydrogenase
EC 1.2.1.57: butanal dehydrogenase
EC 1.2.1.58: phenylglyoxylate dehydrogenase (acylating)
EC 1.2.1.59: glyceraldehyde-3-phosphate dehydrogenase (NAD(P)⁺)
EC 1.2.1.60: 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase
EC 1.2.1.61: 4-hydroxymuconic-semialdehyde dehydrogenase
EC 1.2.1.62: 4-formylbenzenesulfonate dehydrogenase
EC 1.2.1.63: 6-oxohexanoate dehydrogenase
EC 1.2.1.64: 4-hydroxybenzaldehyde dehydrogenase (NAD⁺)
EC 1.2.1.65: salicylaldehyde dehydrogenase
EC 1.2.1.66: Now EC 1.1.1.306, S-(hydroxymethyl)mycothiol dehydrogenase]]
EC 1.2.1.67: vanillin dehydrogenase
EC 1.2.1.68: coniferyl-aldehyde dehydrogenase
EC 1.2.1.69: fluoroacetaldehyde dehydrogenase
EC 1.2.1.70: glutamyl-tRNA reductase
EC 1.2.1.71: succinylglutamate-semialdehyde dehydrogenase
EC 1.2.1.72: erythrose-4-phosphate dehydrogenase
EC 1.2.1.73: sulfoacetaldehyde dehydrogenase
EC 1.2.1.74: abieta-7,13-dien-18-al dehydrogenase
EC 1.2.1.75: malonyl CoA reductase (malonate semialdehyde-forming)
EC 1.2.1.76: succinate-semialdehyde dehydrogenase (acylating)
EC 1.2.1.77: 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase (NADP⁺)
EC 1.2.1.78: 2-formylbenzoate dehydrogenase
EC 1.2.1.79: succinate-semialdehyde dehydrogenase (NADP⁺)
EC 1.2.1.80: long-chain acyl-[acyl-carrier-protein] reductase
EC 1.2.1.81: sulfoacetaldehyde dehydrogenase (acylating)
EC 1.2.1.82: β-apo-4′-carotenal oxygenase
EC 1.2.1.83: 3-succinoylsemialdehyde-pyridine dehydrogenase
EC 1.2.1.84: alcohol-forming fatty acyl-CoA reductase
EC 1.2.1.85: 2-hydroxymuconate-6-semialdehyde dehydrogenase
EC 1.2.1.86: geranial dehydrogenase
EC 1.2.1.87: propanal dehydrogenase (CoA-propanoylating)
EC 1.2.1.88: L-glutamate γ-semialdehyde dehydrogenase
EC 1.2.1.89: D-glyceraldehyde dehydrogenase (NADP⁺)
EC 1.2.1.90: glyceraldehyde-3-phosphate dehydrogenase [NAD(P)⁺]
EC 1.2.1.91: 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase
EC 1.2.1.92: 3,6-anhydro-α-L-galactose dehydrogenase
EC 1.2.1.93: formate dehydrogenase (NAD+, ferredoxin). Now EC 1.17.1.11, formate dehydrogenase (NAD⁺, ferredoxin) *
EC 1.2.1.94: farnesal dehydrogenase
EC 1.2.1.95: L-2-aminoadipate reductase
EC 1.2.1.96: 4-hydroxybenzaldehyde dehydrogenase (⁺+)
EC 1.2.1.97: 3-sulfolactaldehyde dehydrogenase
EC 1.2.1.98: 2-hydroxy-2-methylpropanal dehydrogenase
EC 1.2.1.99: 4-(γ-glutamylamino)butanal dehydrogenase
EC 1.2.1.100: 5-formyl-3-hydroxy-2-methylpyridine 4-carboxylic acid 5-dehydrogenase
EC 1.2.1.101: L-tyrosine reductase
EC 1.2.1.102: isopyridoxal dehydrogenase (5-pyridoxate-forming)
EC 1.2.1.103: [amino-group carrier protein]-6-phospho-L-2-aminoadipate reductase
EC 1.2.1.104: pyruvate dehydrogenase system
EC 1.2.1.105: 2-oxoglutarate dehydrogenase system
EC 1.2.1.106: [amino-group carrier protein]-5-phospho-L-glutamate reductase
EC 1.2.1.107: glyceraldehyde-3-phosphate dehydrogenase (arsenate-transferring)

EC 1.2.2 With a cytochrome as acceptor

EC 1.2.2.1: formate dehydrogenase (cytochrome)
EC 1.2.2.2: Now covered by EC 1.2.5.1, pyruvate dehydrogenase (quinone)
EC 1.2.2.3: Now EC 1.17.2.3, formate dehydrogenase (cytochrome-c-553)
EC 1.2.2.4: Now classified as EC 1.2.5.3, aerobic carbon monoxide dehydrogenase

EC 1.2.3 With oxygen as acceptor

EC 1.2.3.1: aldehyde oxidase
EC 1.2.3.2: Now EC 1.17.3.2, xanthine oxidase
EC 1.2.3.3: pyruvate oxidase
EC 1.2.3.4: oxalate oxidase
EC 1.2.3.5: glyoxylate oxidase
EC 1.2.3.6: pyruvate oxidase (CoA-acetylating)
EC 1.2.3.7: indole-3-acetaldehyde oxidase
EC 1.2.3.8: pyridoxal oxidase
EC 1.2.3.9: aryl-aldehyde oxidase
EC 1.2.3.10: deleted, activity due to EC 1.2.2.4 carbon-monoxide dehydrogenase (cytochrome b-561)
EC 1.2.3.11: retinal oxidase
EC 1.2.3.12: Now included with EC 1.2.3.1, aldehyde oxidase
EC 1.2.3.13: Now EC 1.14.13.82, vanillate monooxygenase
EC 1.2.3.14: Abscisic-aldehyde oxidase
EC 1.2.3.15: (methyl)glyoxal oxidase

EC 1.2.4 With a disulfide as acceptor

EC 1.2.4.1: pyruvate dehydrogenase (acetyl-transferring)
EC 1.2.4.2: oxoglutarate dehydrogenase (succinyl-transferring)
EC 1.2.4.3: Now included with EC 1.2.4.4, 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
EC 1.2.4.4: 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)

EC 1.2.5 With a quinone or similar compound as acceptor

EC 1.2.5.1: pyruvate dehydrogenase (quinone)
EC 1.2.5.2: aldehyde dehydrogenase (quinone)
EC 1.2.5.3: aerobic carbon monoxide dehydrogenase

EC 1.2.7 With an iron–sulfur protein as acceptor

EC 1.2.7.1: pyruvate synthase
EC 1.2.7.2: Now included with EC 1.2.7.1, pyruvate synthase.
EC 1.2.7.3: 2-oxoglutarate synthase
EC 1.2.7.4: anaerobic carbon monoxide dehydrogenase
EC 1.2.7.5: aldehyde ferredoxin oxidoreductase
EC 1.2.7.6: glyceraldehyde-3-phosphate dehydrogenase (ferredoxin)
EC 1.2.7.7: 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)
EC 1.2.7.8: indolepyruvate ferredoxin oxidoreductase
EC 1.2.7.9: deleted, identical to EC 1.2.7.3, 2-oxoglutarate synthase
EC 1.2.7.10: oxalate oxidoreductase
EC 1.2.7.11: 2-oxoacid oxidoreductase (ferredoxin)
EC 1.2.7.12: formylmethanofuran dehydrogenase

===EC 1.2.98: with other,known physiological acceptors===

EC 1.2.98.1: formaldehyde dismutase

===EC 1.2.99: With unknown physiological acceptors===

EC 1.2.99.1: Now EC 1.17.99.4, uracil/thymine dehydrogenase
EC 1.2.99.2: Now EC 1.2.7.4, carbon-monoxide dehydrogenase (ferredoxin)
EC 1.2.99.3: Now EC 1.2.5.2, aldehyde dehydrogenase (quinone)
EC 1.2.99.4: Now EC 1.2.98.1, formaldehyde dismutase
EC 1.2.99.5: Now EC 1.2.7.12, formylmethanofuran dehydrogenase
EC 1.2.99.6: carboxylate reductase
EC 1.2.99.7: aldehyde dehydrogenase (FAD-independent)
EC 1.2.99.8: glyceraldehyde dehydrogenase (FAD-containing)
EC 1.2.99.9: Now EC 1.17.98.3, formate dehydrogenase (coenzyme F₄₂₀)
EC 1.2.99.10: 4,4′-diapolycopenoate synthase

EC 1.3 Acting on the CH-CH group of donors

EC 1.3.1 With NAD⁺ or NADP⁺ as acceptor

EC 1.3.1.1: dihydrouracil dehydrogenase (NAD⁺)
EC 1.3.1.2: dihydropyrimidine dehydrogenase (NADP⁺)
EC 1.3.1.3: Δ⁴-3-oxosteroid 5β-reductase
EC 1.3.1.4: transferred to EC 1.3.1.22, 3-oxo-5α-steroid 4-dehydrogenase (NADP⁺)
EC 1.3.1.5: cucurbitacin Δ²³-reductase
EC 1.3.1.6: fumarate reductase (NADH)
EC 1.3.1.7: meso-tartrate dehydrogenase
EC 1.3.1.8: acyl-CoA dehydrogenase (NADP⁺)
EC 1.3.1.9: enoyl-[acyl-carrier-protein] reductase (NADH)
EC 1.3.1.10: enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)
EC 1.3.1.11: 2-coumarate reductase
EC 1.3.1.12: prephenate dehydrogenase
EC 1.3.1.13: prephenate dehydrogenase (NADP⁺)
EC 1.3.1.14: dihydroorotate dehydrogenase (NAD⁺)
EC 1.3.1.15: dihydroorotate dehydrogenase (NADP⁺)
EC 1.3.1.16: β-nitroacrylate reductase
EC 1.3.1.17: 3-methyleneoxindole reductase
EC 1.3.1.18: kynurenate-7,8-dihydrodiol dehydrogenase
EC 1.3.1.19: cis-1,2-dihydrobenzene-1,2-diol dehydrogenase
EC 1.3.1.20: trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
EC 1.3.1.21: 7-dehydrocholesterol reductase
EC 1.3.1.22: 3-oxo-5α-steroid 4-dehydrogenase (NADP⁺)
EC 1.3.1.23: [[identical to ((EC 1.3.1.3)), ((cortisone b-reductase|Δ4-3-oxosteroid 5β-reductase))|identical to EC 1.3.1.3, Δ4-3-oxosteroid 5β-reductase]]
EC 1.3.1.24: biliverdin reductase
EC 1.3.1.25: 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase
EC 1.3.1.26: Now EC 1.17.1.8, 4-hydroxy-tetrahydrodipicolinate reductase
EC 1.3.1.27: 2-hexadecenal reductase
EC 1.3.1.28: 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
EC 1.3.1.29: cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase
EC 1.3.1.30: transferred to EC 1.3.1.22, 3-oxo-5α-steroid 4-dehydrogenase (NADP⁺)
EC 1.3.1.31: 2-enoate reductase
EC 1.3.1.32: maleylacetate reductase
EC 1.3.1.33: protochlorophyllide reductase
EC 1.3.1.34: 2,4-dienoyl-CoA reductase (NADPH)|2,4-dienoyl-CoA reductase [(2E)-enoyl-CoA-producing]
EC 1.3.1.35: Now EC 1.14.19.22, microsomal oleoyl-lipid 12-desaturase
EC 1.3.1.36: geissoschizine dehydrogenase
EC 1.3.1.37: cis-2-enoyl-CoA reductase (NADPH)
EC 1.3.1.38: trans-2-enoyl-CoA reductase (NADPH)
EC 1.3.1.39: trans-2-enoyl-CoA reductase (NADPH)
EC 1.3.1.40: 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase
EC 1.3.1.41: xanthommatin reductase
EC 1.3.1.42: 12-oxophytodienoate reductase
EC 1.3.1.43: arogenate dehydrogenase
EC 1.3.1.44: trans-2-enoyl-CoA reductase (NAD⁺)
EC 1.3.1.45: 2′-hydroxyisoflavone reductase
EC 1.3.1.46: biochanin-A reductase
EC 1.3.1.47: α-santonin 1,2-reductase
EC 1.3.1.48: 13,14-dehydro-15-oxoprostaglandin 13-reductase
EC 1.3.1.49: cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase
EC 1.3.1.50: n Now EC 1.1.1.252 tetrahydroxynaphthalene reductase
EC 1.3.1.51: 2′-hydroxydaidzein reductase
EC 1.3.1.52: Now EC 1.3.8.5, 2-methyl-branched-chain-enoyl-CoA reductase
EC 1.3.1.53: (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase
EC 1.3.1.54: precorrin-6A reductase
EC 1.3.1.55: identical to EC 1.3.1.25, 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase
EC 1.3.1.56: cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase
EC 1.3.1.57: phloroglucinol reductase
EC 1.3.1.58: 2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase
EC 1.3.1.59: There is no evidence that the enzyme exists
EC 1.3.1.60: dibenzothiophene dihydrodiol dehydrogenase
EC 1.3.1.61: identical to EC 1.3.1.53, (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase
EC 1.3.1.62: pimeloyl-CoA dehydrogenase
EC 1.3.1.63: Now EC 1.21.1.2, 2,4-dichlorobenzoyl-CoA reductase
EC 1.3.1.64: phthalate 4,5-cis-dihydrodiol dehydrogenase
EC 1.3.1.65: 5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase
EC 1.3.1.66: cis-dihydroethylcatechol dehydrogenase
EC 1.3.1.67: cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase
EC 1.3.1.68: 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase
EC 1.3.1.69: zeatin reductase
EC 1.3.1.70: Δ¹⁴-sterol reductase
EC 1.3.1.71: Δ^24(24¹)-sterol reductase
EC 1.3.1.72: Δ²⁴-sterol reductase
EC 1.3.1.73: 1,2-dihydrovomilenine reductase
EC 1.3.1.74: 2-alkenal reductase [NAD(P)⁺]
EC 1.3.1.75: 3,8-divinyl protochlorophyllide a 8-vinyl-reductase (NADPH)
EC 1.3.1.76: precorrin-2 dehydrogenase
EC 1.3.1.77: anthocyanidin reductase [(2R,3R)-flavan-3-ol-forming]
EC 1.3.1.78: arogenate dehydrogenase (NADP⁺)
EC 1.3.1.79: arogenate dehydrogenase (NAD(P)⁺)
EC 1.3.1.80: Now classified as EC 1.3.7.12, red chlorophyll catabolite reductase
EC 1.3.1.81: (+)-pulegone reductase
EC 1.3.1.82: (-)-isopiperitenone reductase
EC 1.3.1.83: geranylgeranyl diphosphate reductase
EC 1.3.1.84: acrylyl-CoA reductase (NADPH)
EC 1.3.1.85: crotonyl-CoA carboxylase/reductase
EC 1.3.1.86: crotonyl-CoA reductase
EC 1.3.1.87: 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase
EC 1.3.1.88: tRNA-dihydrouridine^16/17 synthase (NAD(P)⁺)
EC 1.3.1.89: tRNA-dihydrouridine⁴⁷ synthase (NAD(P)⁺)
EC 1.3.1.90: tRNA-dihydrouridine^20a/20b synthase (NAD(P)⁺)
EC 1.3.1.91: tRNA-dihydrouridine²⁰ synthase (NAD(P)⁺)
EC 1.3.1.92: artemisinic aldehyde Δ¹¹⁽¹³⁾-reductase
EC 1.3.1.93: very-long-chain enoyl-CoA reductase
EC 1.3.1.94: polyprenol reductase
EC 1.3.1.95: acrylyl-CoA reductase (NADH)
EC 1.3.1.96: Botryococcus squalene synthase
EC 1.3.1.97: botryococcene synthase
EC 1.3.1.98: Now known to be catalyzed by two different enzymes, EC 1.3.1.122, (S)-8-oxocitronellyl enol synthase, and EC 5.5.1.34, (+)-cis,trans-nepetalactol synthase
EC 1.3.1.100: chanoclavine-I aldehyde reductase
EC 1.3.1.101: 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H]
EC 1.3.1.102: 2-alkenal reductase (NADP+)
EC 1.3.1.103: 2-haloacrylate reductase
EC 1.3.1.104: enoyl-[acyl-carrier-protein] reductase (NADPH)
EC 1.3.1.105: 2-methylene-furan-3-one reductase
EC 1.3.1.106: cobalt-precorrin-6A reductase
EC 1.3.1.107: sanguinarine reductase
EC 1.3.1.108: caffeoyl-CoA reductase
EC 1.3.1.109: butanoyl-CoA dehydrogenase complex (NAD⁺, ferredoxin)
EC 1.3.1.110: lactate dehydrogenase (NAD⁺,ferredoxin)
EC 1.3.1.111: geranylgeranyl-bacteriochlorophyllide a reductase
EC 1.3.1.112: anthocyanidin reductase [(2S)-flavan-3-ol-forming]
EC 1.3.1.113: (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate reductase
EC 1.3.1.114: 3-dehydro-bile acid Δ^4,6-reductase
EC 1.3.1.115: 3-oxocholoyl-CoA 4-desaturase
EC 1.3.1.116: 7β-hydroxy-3-oxochol-24-oyl-CoA 4-desaturase
EC 1.3.1.117: hydroxycinnamoyl-CoA reductase
EC 1.3.1.118: meromycolic acid enoyl-[acyl-carrier-protein] reductase
EC 1.3.1.119: chlorobenzene dihydrodiol dehydrogenase
EC 1.3.1.120: cyclohexane-1-carbonyl-CoA reductase NADP⁺)
EC 1.3.1.121: 4-amino-4-deoxyprephenate dehydrogenase
EC 1.3.1.122: (S)-8-oxocitronellyl enol synthase
EC 1.3.1.123: 8-oxogeranial reductase
EC 1.3.1.124: 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]

EC 1.3.2 With a cytochrome as acceptor

EC 1.3.2.1: now EC 1.3.99.2
EC 1.3.2.2: now EC 1.3.99.3
EC 1.3.2.3: galactonolactone dehydrogenase

EC 1.3.3 With oxygen as acceptor

EC 1.3.5 With a quinone or related compound as acceptor

EC 1.3.7 With an iron–sulfur protein as acceptor

EC 1.3.8 With a flavin as acceptor

EC 1.3.8.1: short-chain acyl-CoA dehydrogenase
EC 1.3.8.2: 4,4′-diapophytoene desaturase (4,4′-diapolycopene-forming)
EC 1.3.8.3: (R)-benzylsuccinyl-CoA dehydrogenase
EC 1.3.8.4: isovaleryl-CoA dehydrogenase
EC 1.3.8.5: 2-methyl-branched-chain-enoyl-CoA reductase
EC 1.3.8.6: glutaryl-CoA dehydrogenase (ETF)
EC 1.3.8.7: medium-chain acyl-CoA dehydrogenase
EC 1.3.8.8: long-chain acyl-CoA dehydrogenase
EC 1.3.8.9: very-long-chain acyl-CoA dehydrogenase
EC 1.3.8.10: cyclohex-1-ene-1-carbonyl-CoA dehydrogenase
EC 1.3.8.11: cyclohexane-1-carbonyl-CoA dehydrogenase (electron-transfer flavoprotein)
EC 1.3.8.12: (2S)-methylsuccinyl-CoA dehydrogenase
EC 1.3.8.13: crotonobetainyl-CoA reductase
EC 1.3.8.14: L-prolyl-[peptidyl-carrier protein] dehydrogenase
EC 1.3.8.15: 3-(aryl)acrylate reductase
EC 1.3.8.16: 2-amino-4-deoxychorismate dehydrogenase
EC 1.3.8.17: dehydro coenzyme F₄₂₀ reductase

EC 1.3.98 With other,known physiological acceptors

EC 1.3.98.1: dihydroorotate dehydrogenase (fumarate)
EC 1.3.98.2: Now EC 1.3.4.1, fumarate reductase (CoM/CoB)
EC 1.3.98.3: coproporphyrinogen dehydrogenase
EC 1.3.98.4: 5a,11a-dehydrotetracycline reductase
EC 1.3.98.5: hydrogen peroxide-dependent heme synthase
EC 1.3.98.6: AdoMet-dependent heme synthase
EC 1.3.98.7: [mycofactocin precursor peptide]-tyrosine decarboxylase

EC 1.3.99 With unknown physiological acceptors

EC 1.3.99.1: The activity is included in EC 1.3.5.1, succinate dehydrogenase (quinone)
EC 1.3.99.2: Now EC 1.3.8.1, butyryl-CoA dehydrogenase.
EC 1.3.99.3: now EC 1.3.8.7, medium-chain acyl-CoA dehydrogenase, EC 1.3.8.8, long-chain acyl-CoA dehydrogenase and EC 1.3.8.9, very-long-chain acyl-CoA dehydrogenase
EC 1.3.99.4: 3-oxosteroid 1-dehydrogenase
EC 1.3.99.5: 3-oxo-5α-steroid 4-dehydrogenase (acceptor)
EC 1.3.99.6: 3-oxo-5β-steroid 4-dehydrogenase
EC 1.3.99.7: Now EC 1.3.8.6, glutaryl-CoA dehydrogenase
EC 1.3.99.8: 2-furoyl-CoA dehydrogenase
EC 1.3.99.9: Now EC 1.21.99.1, β-cyclopiazonate dehydrogenase
EC 1.3.99.10: Now EC 1.3.8.4, isovaleryl-CoA dehydrogenase
EC 1.3.99.11: transferred to EC 1.3.5.2, dihydroorotate dehydrogenase
EC 1.3.99.12: Now classified as EC 1.3.8.5, 2-methyl-branched-chain-enoyl-CoA reductase
EC 1.3.99.13: Now EC 1.3.8.8, long-chain-acyl-CoA dehydrogenase
EC 1.3.99.14: cyclohexanone dehydrogenase
EC 1.3.99.15: Now EC 1.3.7.8
EC 1.3.99.16: isoquinoline 1-oxidoreductase
EC 1.3.99.17: quinoline 2-oxidoreductase
EC 1.3.99.18: quinaldate 4-oxidoreductase
EC 1.3.99.19: quinoline-4-carboxylate 2-oxidoreductase
EC 1.3.99.20: Now EC 1.3.7.9, 4-hydroxybenzoyl-CoA reductase
EC 1.3.99.21: Now EC 1.3.8.3, (R)-benzylsuccinyl-CoA dehydrogenase
EC 1.3.99.22: Now EC 1.3.98.3, coproporphyrinogen dehydrogenase
EC 1.3.99.23: all-trans-retinol 13,14-reductase
EC 1.3.99.24: Now EC 1.3.8.16, 2-amino-4-deoxychorismate dehydrogenase
EC 1.3.99.25: carvone reductase
EC 1.3.99.26: all-trans-ζ-carotene desaturase
EC 1.3.99.27: 1-hydroxycarotenoid 3,4-desaturase
EC 1.3.99.28: phytoene desaturase (neurosporene-forming)
EC 1.3.99.29: phytoene desaturase (zeta-carotene-forming)
EC 1.3.99.30: phytoene desaturase (3,4-didehydrolycopene-forming)
EC 1.3.99.31: phytoene desaturase (lycopene-forming)
EC 1.3.99.32: glutaryl-CoA dehydrogenase (non-decarboxylating)
EC 1.3.99.33: urocanate reductase
EC 1.3.99.34: Now classified as EC 1.3.7.11, 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase
EC 1.3.99.35: Now EC 1.3.7.15, chlorophyllide a reductase *
EC 1.3.99.36: cypemycin cysteine dehydrogenase (decarboxylating)
EC 1.3.99.37: 1-hydroxy-2-isopentenylcarotenoid 3,4-desaturase
EC 1.3.99.38: menaquinone-9 β-reductase
EC 1.3.99.39: carotenoid φ-ring synthase
EC 1.3.99.40: carotenoid χ-ring synthase

EC 1.4 Acting on the CH-NH₂ group of donors

EC 1.4.1 With NAD⁺ or NADP⁺ as acceptor

EC 1.4.1.1: alanine dehydrogenase
EC 1.4.1.2: glutamate dehydrogenase
EC 1.4.1.3: glutamate dehydrogenase (NAD(P)⁺)
EC 1.4.1.4: glutamate dehydrogenase (NADP⁺)
EC 1.4.1.5: L-amino-acid dehydrogenase
EC 1.4.1.6: deleted, Now included with EC 1.21.4.1, D-proline reductase (dithiol)
EC 1.4.1.7: serine 2-dehydrogenase
EC 1.4.1.8: valine dehydrogenase (NADP⁺)
EC 1.4.1.9: leucine dehydrogenase
EC 1.4.1.10: glycine dehydrogenase
EC 1.4.1.11: L-erythro-3,5-diaminohexanoate dehydrogenase
EC 1.4.1.12: 2,4-diaminopentanoate dehydrogenase
EC 1.4.1.13: glutamate synthase (NADPH)
EC 1.4.1.14: glutamate synthase (NADH)
EC 1.4.1.15: lysine dehydrogenase
EC 1.4.1.16: diaminopimelate dehydrogenase
EC 1.4.1.17: N-methylalanine dehydrogenase
EC 1.4.1.18: lysine 6-dehydrogenase
EC 1.4.1.19: tryptophan dehydrogenase
EC 1.4.1.20: phenylalanine dehydrogenase
EC 1.4.1.21: aspartate dehydrogenase
EC 1.4.1.22: there is no overall consumption of NAD⁺ during the reaction. As a result, transfer of the enzyme from EC 4.3.1.12 was not necessary and EC 1.4.1.22 was withdrawn before being made official
EC 1.4.1.23: valine dehydrogenase (NAD⁺)
EC 1.4.1.24: 3-dehydroquinate synthase II
EC 1.4.1.25: L-arginine dehydrogenase
EC 1.4.1.26: 2,4-diaminopentanoate dehydrogenase (NAD⁺)
EC 1.4.1.27: glycine cleavage system

EC 1.4.2 With a cytochrome as acceptor

EC 1.4.2.1: glycine dehydrogenase (cytochrome)

EC 1.4.3 With oxygen as acceptor

EC 1.4.3.1: D-aspartate oxidase
EC 1.4.3.2: L-amino-acid oxidase
EC 1.4.3.3: D-amino-acid oxidase
EC 1.4.3.4: monoamine oxidase
EC 1.4.3.5: pyridoxal 5′-phosphate synthase
EC 1.4.3.6: replaced by two enzymes, EC 1.4.3.21 (primary-amine oxidase) and EC 1.4.3.22 (diamine oxidase)
EC 1.4.3.7: D-glutamate oxidase
EC 1.4.3.8: ethanolamine oxidase
EC 1.4.3.9: Now included with EC 1.4.3.4 amine oxidase (flavin-containing)
EC 1.4.3.10: putrescine oxidase
EC 1.4.3.11: L-glutamate oxidase
EC 1.4.3.12: cyclohexylamine oxidase
EC 1.4.3.13: protein-lysine 6-oxidase
EC 1.4.3.14: L-lysine oxidase
EC 1.4.3.15: D-glutamate(D-aspartate) oxidase
EC 1.4.3.16: L-aspartate oxidase
EC 1.4.3.17: Now EC 1.3.3.10, tryptophan α,β-oxidase
EC 1.4.3.18: Not approved as the enzyme was shown to be a dehydrogenase and not an oxidase (see EC 1.5.99.12, cytokinin dehydrogenase)
EC 1.4.3.19: glycine oxidase
EC 1.4.3.20: L-lysine 6-oxidase
EC 1.4.3.21: primary-amine oxidase
EC 1.4.3.22: diamine oxidase
EC 1.4.3.23: 7-chloro-L-tryptophan oxidase
EC 1.4.3.24: pseudooxynicotine oxidase
EC 1.4.3.25: L-arginine oxidase
EC 1.4.3.26: pre-mycofactocin synthase

EC 1.4.4 With a disulfide as acceptor

EC 1.4.4.1: Now EC 1.21.4.1, D-proline reductase (dithiol)
EC 1.4.4.2: glycine dehydrogenase (aminomethyl-transferring)

EC 1.4.5 With a quinone or other compound as acceptor

EC 1.4.5.1: D-amino acid dehydrogenase (quinone)

EC 1.4.7 With an iron–sulfur protein as acceptor

EC 1.4.7.1: glutamate synthase (ferredoxin)

EC 1.4.9 With a copper protein as acceptor

EC 1.4.98 With other, known physiological acceptors

EC 1.4.98.1: NOW 1.4.9.1 methylamine dehydrogenase (amicyanin)

EC 1.4.99 With unknown physiological acceptors

EC 1.4.99.1: Now EC 1.4.99.6, D-arginine dehydrogenase
EC 1.4.99.2: taurine dehydrogenase
EC 1.4.99.3: Now EC 1.4.9.1, methylamine dehydrogenase (amicyanin)
EC 1.4.99.4: Now EC 1.4.9.2, aralkylamine dehydrogenase (azurin)
EC 1.4.99.5: glycine dehydrogenase (cyanide-forming)
EC 1.4.99.6: D-arginine dehydrogenase

EC 1.5 Acting on the CH-NH group of donors

EC 1.5.1 With NAD⁺ or NADP⁺ as acceptor

EC 1.5.1.1: 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H
EC 1.5.1.2: pyrroline-5-carboxylate reductase
EC 1.5.1.3: dihydrofolate reductase
EC 1.5.1.4: Now included with EC 1.5.1.3 dihydrofolate reductase
EC 1.5.1.5: methylenetetrahydrofolate dehydrogenase (NADP⁺)
EC 1.5.1.6: formyltetrahydrofolate dehydrogenase
EC 1.5.1.7: saccharopine dehydrogenase (NAD⁺, L-lysine-forming)
EC 1.5.1.8: saccharopine dehydrogenase (NADP⁺, L-lysine-forming)
EC 1.5.1.9: saccharopine dehydrogenase (NAD⁺, L-glutamate-forming)
EC 1.5.1.10: saccharopine dehydrogenase (NADP⁺, L-glutamate-forming)
EC 1.5.1.11: D-octopine dehydrogenase
EC 1.5.1.12: Now EC 1.2.1.88, L-glutamate γ-semialdehyde dehydrogenase
EC 1.5.1.13: Now EC 1.17.1.5, nicotinate dehydrogenase
EC 1.5.1.14: Now included with EC 1.5.1.21 Δ¹-piperideine-2-carboxylate reductase
EC 1.5.1.15: methylenetetrahydrofolate dehydrogenase (NAD⁺)
EC 1.5.1.16: D-lysopine dehydrogenase
EC 1.5.1.17: alanopine dehydrogenase
EC 1.5.1.18: ephedrine dehydrogenase
EC 1.5.1.19: D-nopaline dehydrogenase
EC 1.5.1.20: methylenetetrahydrofolate reductase (NAD(P)H)
EC 1.5.1.21: 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH)
EC 1.5.1.22: strombine dehydrogenase
EC 1.5.1.23: tauropine dehydrogenase
EC 1.5.1.24: N⁵-(carboxyethyl)ornithine synthase
EC 1.5.1.25: thiomorpholine-carboxylate dehydrogenase
EC 1.5.1.26: β-alanopine dehydrogenase
EC 1.5.1.27: 1,2-dehydroreticulinium reductase (NADPH)
EC 1.5.1.28: opine dehydrogenase
EC 1.5.1.29: Now covered by EC 1.5.1.38 [FMN reductase (NADPH)], EC 1.5.1.39 [FMN reductase [NAD(P)H])] and EC 1.5.1.41 (riboflavin reductase [NAD(P)H])
EC 1.5.1.30: flavin reductase (NADPH)
EC 1.5.1.31: berberine reductase
EC 1.5.1.32: vomilenine reductase
EC 1.5.1.33: pteridine reductase
EC 1.5.1.34: 6,7-dihydropteridine reductase
EC 1.5.1.35: identical to EC 1.2.1.19, aminobutyraldehyde dehydrogenase, as the substrates 1-pyrroline and 4-aminobutanal are interconvertible
EC 1.5.1.36: flavin reductase (NADH)
EC 1.5.1.37: FAD reductase (NADH)
EC 1.5.1.38: FMN reductase (NADPH)
EC 1.5.1.39: FMN reductase (NAD(P)H)
EC 1.5.1.40: 8-hydroxy-5-deazaflavin:NADPH oxidoreductase
EC 1.5.1.41: riboflavin reductase (NAD(P)H)
EC 1.5.1.42: FMN reductase (NADH)
EC 1.5.1.43: carboxynorspermidine synthase
EC 1.5.1.44: festuclavine dehydrogenase
EC 1.5.1.45: FAD reductase (NAD(P)H)
EC 1.5.1.46: agroclavine dehydrogenase
EC 1.5.1.47: dihydromethanopterin reductase [NAD(P)⁺]
EC 1.5.1.48: 2-methyl-1-pyrroline reductase
EC 1.5.1.49: 1-pyrroline-2-carboxylate reductase [NAD(P)H]
EC 1.5.1.50: dihydromonapterin reductase
EC 1.5.1.51: N-[(2S)-2-amino-2-carboxyethyl]-L-lutamate dehydrogenase
EC 1.5.1.52: staphylopine dehydrogenase
EC 1.5.1.53: methylenetetrahydrofolate reductase (NADPH)
EC 1.5.1.54: methylenetetrahydrofolate reductase (NADH)

EC 1.5.3 With oxygen as acceptor

EC 1.5.3.1: sarcosine oxidase
EC 1.5.3.2: N-methyl-L-amino-acid oxidase
EC 1.5.3.3: deleted
EC 1.5.3.4: N⁶-methyl-lysine oxidase
EC 1.5.3.5: (S)-6-hydroxynicotine oxidase
EC 1.5.3.6: (R)-6-hydroxynicotine oxidase
EC 1.5.3.7: L-pipecolate oxidase
EC 1.5.3.8: Now included with EC 1.3.3.8, tetrahydroberberine oxidase
EC 1.5.3.9: Now EC 1.21.3.3, reticuline oxidase
EC 1.5.3.10: dimethylglycine oxidase
EC 1.5.3.11: Now included with EC 1.5.3.13 (N¹-acetylpolyamine oxidase), EC 1.5.3.14 (polyamine oxidase (propane-1,3-diamine-forming)), EC 1.5.3.15 (N⁸-acetylspermidine oxidase (propane-1,3-diamine-forming)), EC 1.5.3.16 (spermine oxidase) and EC 1.5.3.17 (non-specific polyamine oxidase)
EC 1.5.3.12: dihydrobenzophenanthridine oxidase
EC 1.5.3.13: N¹-acetylpolyamine oxidase
EC 1.5.3.14: polyamine oxidase (propane-1,3-diamine-forming)
EC 1.5.3.15: N⁸-acetylspermidine oxidase (propane-1,3-diamine-forming)
EC 1.5.3.16: spermine oxidase
EC 1.5.3.17: non-specific polyamine oxidase
EC 1.5.3.18: L-saccharopine oxidase
EC 1.5.3.19: 4-methylaminobutanoate oxidase (formaldehyde-forming)
EC 1.5.3.20: N-alkylglycine oxidase
EC 1.5.3.21: 4-methylaminobutanoate oxidase (methylamine-forming)
EC 1.5.3.22: coenzyme F₄₂₀H₂ oxidase
EC 1.5.3.23: glyphosate oxidoreductase

EC 1.5.4 With a disulfide as acceptor

EC 1.5.4.1: pyrimidodiazepine synthase

EC 1.5.5 With a quinone or similar compound as acceptor

EC 1.5.5.1: electron-transferring-flavoprotein dehydrogenase
EC 1.5.5.2: proline dehydrogenase
EC 1.5.5.3: hydroxyproline dehydrogenase

EC 1.5.7 With an iron–sulfur protein as acceptor

EC 1.5.8 With a flavin or flavoprotein as acceptor

EC 1.5.98 With other, known, physiological acceptors

EC 1.5.98.1: ethylenetetrahydromethanopterin dehydrogenase
EC 1.5.98.2: 5,10-methylenetetrahydromethanopterin reductase
EC 1.5.98.3: coenzyme F₄₂₀:methanophenazine dehydrogenase

EC 1.5.99 With unknown physiological acceptors

EC 1.5.99.1: Now EC 1.5.8.3, sarcosine dehydrogenase
EC 1.5.99.2: Now EC 1.5.8.4, dimethylglycine dehydrogenase
EC 1.5.99.3: L-pipecolate dehydrogenase
EC 1.5.99.4: nicotine dehydrogenase
EC 1.5.99.5: methylglutamate dehydrogenase
EC 1.5.99.6: spermidine dehydrogenase
EC 1.5.99.7: Now EC 1.5.8.2, trimethylamine dehydrogenase
EC 1.5.99.8: Now EC 1.5.5.2, proline dehydrogenase
EC 1.5.99.9: transferred to EC 1.5.98.1, methylenetetrahydromethanopterin dehydrogenase
EC 1.5.99.10: Now EC 1.5.8.1, dimethylamine dehydrogenase
EC 1.5.99.11: transferred to EC 1.5.98.2, 5,10-methylenetetrahydromethanopterin reductase
EC 1.5.99.12: cytokinin dehydrogenase
EC 1.5.99.13: D-proline dehydrogenase
EC 1.5.99.14: 6-hydroxypseudooxynicotine dehydrogenase
EC 1.5.99.15: dihydromethanopterin reductase (acceptor)

EC 1.6 Acting on NADH or NADPH

EC 1.6.1 With NAD or NADP as acceptor

EC 1.6.2 With a heme protein as acceptor

EC 1.6.2.1: now EC 1.6.99.3 NADH dehydrogenase
EC 1.6.2.2: cytochrome-b₅ reductase
EC 1.6.2.3: deleted
EC 1.6.2.4: NADPH—hemoprotein reductase
EC 1.6.2.5: NADPH—cytochrome-c₂ reductase
EC 1.6.2.6: leghemoglobin reductase

EC 1.6.3 With oxygen as acceptor

EC 1.6.3.1: NAD(P)H oxidase (H₂O₂-forming)
EC 1.6.3.2: NAD(P)H oxidase (H₂O-forming)
EC 1.6.3.3: NADH oxidase (H₂O₂-forming)
EC 1.6.3.4: NADH oxidase (H₂O-forming)
EC 1.6.3.5: renalase

EC 1.6.4 With a disulfide as acceptor (deleted sub-class)

EC 1.6.4.1: now EC 1.8.1.6 cystine reductase
EC 1.6.4.2: now EC 1.8.1.7 glutathione-disulfide reductase
EC 1.6.4.3: now EC 1.8.1.4 dihydrolipoyl dehydrogenase
EC 1.6.4.4: now EC 1.8.1.8 protein-disulfide reductase
EC 1.6.4.5: now EC 1.8.1.9 thioredoxin-disulfide reductase
EC 1.6.4.6: now EC 1.8.1.10 CoA-glutathione reductase
EC 1.6.4.7: now EC 1.8.1.11 asparagusate reductase
EC 1.6.4.8: now EC 1.8.1.12 trypanothione-disulfide reductase
EC 1.6.4.9: now EC 1.8.1.13 bis-γ-glutamylcystine reductase
EC 1.6.4.10: now EC 1.8.1.14 CoA-disulfide reductase

EC 1.6.5 With a quinone or similar compound as acceptor

EC 1.6.5.1: deleted
EC 1.6.5.2: NAD(P)H dehydrogenase (quinone)
EC 1.6.5.3: now EC 7.1.1.2 NADH:ubiquinone reductase (H⁺-translocating)
EC 1.6.5.4: monodehydroascorbate reductase (NADH)
EC 1.6.5.5: NADPH:quinone reductase
EC 1.6.5.6: p-benzoquinone reductase (NADPH)
EC 1.6.5.7: 2-hydroxy-1,4-benzoquinone reductase
EC 1.6.5.8: Now EC 7.2.1.1, NADH:ubiquinone reductase (Na⁺-transporting)
EC 1.6.5.9: NADH:ubiquinone reductase (non-electrogenic)
EC 1.6.5.10: NADPH dehydrogenase (quinone)
EC 1.6.5.11: [[Identical to EC 1.6.5.9, NADH:quinone reductase (non-electrogenic)]]
EC 1.6.5.12: demethylphylloquinone reductase

EC 1.6.6 With a nitrogenous group as acceptor

EC 1.6.6.1: Now EC 1.7.1.1, nitrate reductase (NADH)
EC 1.6.6.2: Now EC 1.7.1.2, nitrate reductase [NAD(P)H]
EC 1.6.6.3: Now EC 1.7.1.3, nitrate reductase (NADPH)
EC 1.6.6.4: Now EC 1.7.1.4, nitrite reductase [NAD(P)H]
EC 1.6.6.5: Now EC 1.7.2.1, nitrite reductase (NO-forming)
EC 1.6.6.6: Now EC 1.7.1.5, hyponitrite reductase
EC 1.6.6.7: Now EC 1.7.1.6, azobenzene reductase
EC 1.6.6.8: Now EC 1.7.1.7, GMP reductase
EC 1.6.6.9: Now known to be catalysed by EC 1.7.2.3, trimethylamine-N-oxide reductase
EC 1.6.6.10: Now EC 1.7.1.9, nitroquinoline-N-oxide reductase]
EC 1.6.6.11: Now EC 1.7.1.10, hydroxylamine reductase (NADH)
EC 1.6.6.12: Now EC 1.7.1.11, 4-(dimethylamino)phenylazoxybenzene reductase
EC 1.6.6.13: Now EC 1.7.1.12, N-hydroxy-2-acetamidofluorene reductase

EC 1.6.7 With an iron–sulfur protein as acceptor (deleted sub-subclass)

EC 1.6.7.1: now EC 1.18.1.2 ferredoxin—NADP⁺ reductase
EC 1.6.7.2: now EC 1.18.1.1 rubredoxin—NAD⁺ reductase
EC 1.6.7.3: now EC 1.18.1.3 ferredoxin—NAD⁺ reductase

EC 1.6.8 With a flavin as acceptor (deleted sub-subclass)

EC 1.6.8.1: Now EC 1.5.1.29 FMN reductase
EC 1.6.8.2: Now EC 1.5.1.30 flavin reductase

EC 1.6.99 With unknown physiological acceptors

EC 1.6.99.1: NADPH dehydrogenase
EC 1.6.99.2: Now EC 1.6.5.2, NAD(P)H dehydrogenase (quinone
EC 1.6.99.3: [[The activity is covered by EC 7.1.1.2, NADH:ubiquinone reductase (H+-translocating)|The activity is covered by EC 7.1.1.2, NADH:ubiquinone reductase (H⁺-translocating)]]
EC 1.6.99.4: Now EC 1.18.1.2, ferredoxin—NADP⁺ reductase
EC 1.6.99.5: Now EC 1.6.5.11, NADH dehydrogenase (quinone)
EC 1.6.99.6: Now EC 1.6.5.10, NADPH dehydrogenase (quinone)
EC 1.6.99.7: Now EC 1.5.1.34, 6,7-dihydropteridine reductase
EC 1.6.99.8: Deleted
EC 1.6.99.9: Now EC 1.16.1.4, cob(II)alamin reductase
EC 1.6.99.10: included in EC 1.5.1.34, 6,7-dihydropteridine reductase
EC 1.6.99.11: Deleted
EC 1.6.99.12: Now EC 1.16.1.6, cyanocobalamin reductase (cyanide-eliminating)
EC 1.6.99.13: Now EC 1.16.1.7, ferric-chelate reductase

EC 1.7 Acting on other nitrogenous compounds as donors

EC 1.7.1 With NAD⁺ or NADP⁺ as acceptor

EC 1.7.2 With a cytochrome as acceptor

EC 1.7.3 With oxygen as acceptor

EC 1.7.3.1: nitroalkane oxidase
EC 1.7.3.2: acetylindoxyl oxidase
EC 1.7.3.3: factor-independent urate hydroxylase
EC 1.7.3.4: Now covered by EC 1.7.2.6, hydroxylamine dehydrogenase, and EC 1.7.3.6, hydroxylamine oxidase (cytochrome)
EC 1.7.3.5: 3-aci-nitropropanoate oxidase
EC 1.7.3.6: hydroxylamine oxidase (cytochrome)

EC 1.7.5 With a quinone or similar compound as acceptor

EC 1.7.6 With a nitrogenous group as acceptor

EC 1.7.6.1: nitrite dismutase

EC 1.7.7 With an iron–sulfur protein as acceptor

EC 1.7.99 With other acceptors

EC 1.7.99.1: hydroxylamine reductase
EC 1.7.99.2: deleted: reaction may have been due to the combined action of EC 1.7.99.6 nitrous-oxide reductase and EC 1.7.99.7 nitric-oxide reductase
EC 1.7.99.3: Now included with EC 1.7.2.1, nitrite reductase (NO-forming)
EC 1.7.99.4: Now EC 1.7.1.1, nitrate reductase (NADH), EC 1.7.1.2, nitrate reductase [NAD(P)H], EC 1.7.1.3, nitrate reductase (NADPH), EC 1.7.5.1, nitrate reductase (quinone), EC 1.7.7.2, nitrate reductase (ferredoxin) and EC 1.9.6.1, nitrate reductase (cytochrome)
EC 1.7.99.5: Now included with EC 1.5.1.20, methylenetetrahydrofolate reductase [NAD(P)H]
EC 1.7.99.6: Now EC 1.7.2.4 nitrous-oxide reductase
EC 1.7.99.7: Now EC 1.7.2.5 nitric oxide reductase (cytochrome c)
EC 1.7.99.8: hydroxylamine oxidoreductase
EC 1.7.99.8: Now classified as EC 1.7.2.8, hydrazine dehydrogenase

EC 1.8 Acting on a sulfur group of donors

EC 1.8.1 With NAD⁺ or NADP⁺ as acceptor

EC 1.8.2 With a cytochrome as acceptor

EC 1.8.3 With oxygen as acceptor

EC 1.8.4 With a disulfide as acceptor

EC 1.8.4.1: glutathione—homocystine transhydrogenase
EC 1.8.4.2: protein-disulfide reductase (glutathione)
EC 1.8.4.3: glutathione—CoA-glutathione transhydrogenase
EC 1.8.4.4: glutathione—cystine transhydrogenase
EC 1.8.4.5: Now EC 1.8.4.13, L-methionine (S)-S-oxide reductase and EC 1.8.4.14, L-methionine (R)-S-oxide reductase
EC 1.8.4.6: [[due to EC 1.8.4.11, peptide-methionine (S)-S-oxide reductase|due to EC 1.8.4.11, peptide-methionine (S)-S-oxide reductase]]
EC 1.8.4.7: enzyme-thiol transhydrogenase (glutathione-disulfide)
EC 1.8.4.8: phosphoadenylyl-sulfate reductase (thioredoxin)
EC 1.8.4.9: adenylyl-sulfate reductase (glutathione)
EC 1.8.4.10: adenylyl-sulfate reductase (thioredoxin)
EC 1.8.4.11: peptide-methionine (S)-S-oxide reductase
EC 1.8.4.12: peptide-methionine (R)-S-oxide reductase
EC 1.8.4.13: L-methionine (S)-S-oxide reductase
EC 1.8.4.14: L-methionine (R)-S-oxide reductase
EC 1.8.4.15: protein dithiol oxidoreductase (disulfide-forming)
EC 1.8.4.16: thioredoxin:protein disulfide reductase

EC 1.8.5 With a quinone or similar compound as acceptor

EC 1.8.6 With a nitrogenous group as acceptor (deleted sub-subclass)

EC 1.8.6.1: Now included with EC 2.5.1.18 glutathione transferase

EC 1.8.7 With an iron–sulfur protein as acceptor

EC 1.8.98 With other, known, acceptors

EC 1.8.99 With other acceptors

EC 1.8.99.1: Now covered by EC 1.8.1.2, assimilatory sulfite reductase (NADPH) and EC 1.8.7.1, assimilatory sulfite reductase (ferredoxin)
EC 1.8.99.2: adenylyl-sulfate reductase
EC 1.8.99.3: [[an in vitro artifact of EC 1.8.99.5, dissimilatory sulfite reductase|an in vitro artifact of EC 1.8.99.5, dissimilatory sulfite reductase]]
EC 1.8.99.4: Now EC 1.8.4.8, phosphoadenylyl-sulfate reductase (thioredoxin)
EC 1.8.99.5: dissimilatory sulfite reductase

EC 1.9 Acting on a heme group of donors

EC 1.9.3 With oxygen as acceptor

EC 1.9.3.1: Now EC 7.1.1.9, cytochrome-c oxidase
EC 1.9.3.2: Now included with EC 1.7.2.1, nitrite reductase (NO-forming)

EC 1.9.6 With a nitrogenous group as acceptor

EC 1.9.6.1: nitrate reductase (cytochrome)

EC 1.9.98 With other, known, physiological acceptors

EC 1.9.98.1: iron—cytochrome-c reductase

EC 1.9.99 With other acceptors

EC 1.9.99.1: Now EC 1.9.98.1, iron—cytochrome-c reductase

EC 1.10 Acting on diphenols and related substances as donors

EC 1.10.1 With NAD⁺ or NADP⁺ as acceptor

EC 1.10.1.1: trans-acenaphthene-1,2-diol dehydrogenase

EC 1.10.2 With a cytochrome as acceptor

EC 1.10.2.1: [[The activity is covered by EC 7.2.1.3, ascorbate ferrireductase (transmembrane)]]
EC 1.10.2.2: Now EC 7.1.1.8, quinol—cytochrome-c reductase

EC 1.10.3 With oxygen as acceptor

EC 1.10.3.1: catechol oxidase
EC 1.10.3.2: laccase
EC 1.10.3.3: L-ascorbate oxidase
EC 1.10.3.4: o-aminophenol oxidase
EC 1.10.3.5: 3-hydroxyanthranilate oxidase
EC 1.10.3.6: rifamycin-B oxidase
EC 1.10.3.7: Now EC 1.21.3.4, sulochrin oxidase [(+)-bisdechlorogeodin-forming]
EC 1.10.3.8: Now EC 1.21.3.5, sulochrin oxidase [(-)-bisdechlorogeodin-forming]
EC 1.10.3.9: photosystem II
EC 1.10.3.10: Now EC 7.1.1.3, ubiquinol oxidase (H⁺-transporting)
EC 1.10.3.11: ubiquinol oxidase (non-electrogenic)
EC 1.10.3.12: Now EC 7.1.1.5, menaquinol oxidase (H⁺-transporting)
EC 1.10.3.13: Now EC 7.1.1.4, caldariellaquinol oxidase (H⁺-transporting)
EC 1.10.3.14: Now EC 7.1.1.7, ubiquinol oxidase (electrogenic, proton-motive force generating)
EC 1.10.3.15: grixazone synthase
EC 1.10.3.16: dihydrophenazinedicarboxylate synthase
EC 1.10.3.17: superoxide oxidase

EC 1.10.5 With a quinone or related compound as acceptor

EC 1.10.5.1: ribosyldihydronicotinamide dehydrogenase (quinone)

EC 1.10.9 With a copper protein as acceptor

EC 1.10.9.1: Now EC 7.1.1.6, plastoquinol—plastocyanin reductase

EC 1.10.99 With unknown physiological acceptors

EC 1.10.99.1: Now EC 1.10.9.1 plastoquinol—plastocyanin reductase
EC 1.10.99.2: Now EC 1.10.5.1 ribosyldihydronicotinamide dehydrogenase (quinone)
EC 1.10.99.3: Now EC 1.23.5.1 violaxanthin de-epoxidase

EC 1.11 Acting on a peroxide as acceptor

EC 1.11.1 Peroxidases

EC 1.11.1.1: NADH peroxidase
EC 1.11.1.2: NADPH peroxidase
EC 1.11.1.3: fatty-acid peroxidase
EC 1.11.1.4: Now EC 1.13.11.11 EC 1.13.11.11 tryptophan 2,3-dioxygenase
EC 1.11.1.5: cytochrome-c peroxidase
EC 1.11.1.6: catalase
EC 1.11.1.7: peroxidase
EC 1.11.1.8: iodide peroxidase
EC 1.11.1.9: glutathione peroxidase
EC 1.11.1.10: chloride peroxidase
EC 1.11.1.11: L-ascorbate peroxidase
EC 1.11.1.12: phospholipid-hydroperoxide glutathione peroxidase
EC 1.11.1.13: manganese peroxidase
EC 1.11.1.14: lignin peroxidase
EC 1.11.1.15: Now described by EC 1.11.1.24, thioredoxin-dependent peroxiredoxin; EC 1.11.1.25, glutaredoxin-dependent peroxiredoxin; EC 1.11.1.26, NADH-dependent peroxiredoxin; EC 1.11.1.27, glutathione-dependent peroxiredoxin; EC 1.11.1.28, lipoyl-dependent peroxiredoxin; and EC 1.11.1.29, mycoredoxin-dependent peroxiredoxin
EC 1.11.1.16: versatile peroxidase
EC 1.11.1.17: glutathione amide-dependent peroxidase
EC 1.11.1.18: bromide peroxidase
EC 1.11.1.19: dye decolorizing peroxidase
EC 1.11.1.20: prostamide/prostaglandin F_2α synthase
EC 1.11.1.21: catalase-peroxidase
EC 1.11.1.22: hydroperoxy fatty acid reductase
EC 1.11.1.23: (S)-2-hydroxypropylphosphonic acid epoxidase
EC 1.11.1.24: thioredoxin-dependent peroxiredoxin
EC 1.11.1.25: glutaredoxin-dependent peroxiredoxin
EC 1.11.1.26: NADH-dependent peroxiredoxin
EC 1.11.1.27: glutathione-dependent peroxiredoxin
EC 1.11.1.28: lipoyl-dependent peroxiredoxin
EC 1.11.1.29: mycoredoxin-dependent peroxiredoxin

EC 1.11.2 Peroxygenase

EC 1.12 Acting on hydrogen as donor

EC 1.12.1 With NAD⁺ or NADP⁺ as acceptor

EC 1.12.1.1: Now EC 1.12.7.2, ferredoxin hydrogenase
EC 1.12.1.2: hydrogen dehydrogenase
EC 1.12.1.3: hydrogen dehydrogenase (NADP⁺)
EC 1.12.1.4: hydrogenase (NAD⁺, ferredoxin)
EC 1.12.1.5: hydrogen dehydrogenase [NAD(P)⁺]

EC 1.12.2 With a cytochrome as acceptor

EC 1.12.2.1: cytochrome-c₃ hydrogenase

EC 1.12.5 With a quinone or similar compound as acceptor

EC 1.12.5.1: hydrogen:quinone oxidoreductase

EC 1.12.7 With an iron–sulfur protein as acceptor

EC 1.12.7.1: Now EC 1.12.7.2, ferredoxin hydrogenase
EC 1.12.7.2: ferredoxin hydrogenase

EC 1.12.98 With other known acceptors

EC 1.12.99 With unknown physiological acceptors

EC 1.12.99.1: Now EC 1.12.98.1, coenzyme F₄₂₀ hydrogenase
EC 1.12.99.2: Now shown to be two enzymes, EC 1.12.98.3, Methanosarcina-phenazine hydrogenase and EC 1.8.98.1, CoB—CoM heterodisulfide reductase
EC 1.12.99.3: Now EC 1.12.5.1, hydrogen:quinone oxidoreductase
EC 1.12.99.4: Now EC 1.12.98.2, 5,10-methenyltetrahydromethanopterin hydrogenase
EC 1.12.99.5: [[Identical to EC 1.13.11.47, 3-hydroxy-4-oxoquinoline 2,4-dioxygenase]]
EC 1.12.99.6: hydrogenase (acceptor)

EC 1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

EC 1.13.11 With incorporation of two atoms of oxygen

EC 1.13.11.1: catechol 1,2-dioxygenase
EC 1.13.11.2: catechol 2,3-dioxygenase
EC 1.13.11.3: protocatechuate 3,4-dioxygenase
EC 1.13.11.4: gentisate 1,2-dioxygenase
EC 1.13.11.5: homogentisate 1,2-dioxygenase
EC 1.13.11.6: 3-hydroxyanthranilate 3,4-dioxygenase
EC 1.13.11.7: deleted
EC 1.13.11.8: protocatechuate 4,5-dioxygenase
EC 1.13.11.9: 2,5-dihydroxypyridine 5,6-dioxygenase
EC 1.13.11.10: 7,8-dihydroxykynurenate 8,8a-dioxygenase
EC 1.13.11.11: tryptophan 2,3-dioxygenase
EC 1.13.11.12: linoleate 13S-lipoxygenas
EC 1.13.11.13: The activity is the sum of several enzymatic and spontaneous reactions
EC 1.13.11.14: 2,3-dihydroxybenzoate 3,4-dioxygenase
EC 1.13.11.15: 3,4-dihydroxyphenylacetate 2,3-dioxygenase
EC 1.13.11.16: 3-carboxyethylcatechol 2,3-dioxygenase
EC 1.13.11.17: indole 2,3-dioxygenase
EC 1.13.11.18: persulfide dioxygenase
EC 1.13.11.19: cysteamine dioxygenase
EC 1.13.11.20: cysteine dioxygenase
EC 1.13.11.21: Now EC 1.14.99.36, β-carotene 15,15′-monooxygenase
EC 1.13.11.22: caffeate 3,4-dioxygenase
EC 1.13.11.23: 2,3-dihydroxyindole 2,3-dioxygenase
EC 1.13.11.24: quercetin 2,3-dioxygenase
EC 1.13.11.25: 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase
EC 1.13.11.26: peptide-tryptophan 2,3-dioxygenase
EC 1.13.11.27: 4-hydroxyphenylpyruvate dioxygenase
EC 1.13.11.28: 2,3-dihydroxybenzoate 2,3-dioxygenase
EC 1.13.11.29: stizolobate synthase
EC 1.13.11.30: stizolobinate synthase
EC 1.13.11.31: arachidonate 12-lipoxygenase
EC 1.13.11.32: Now EC 1.13.12.16, nitronate monooxygenase
EC 1.13.11.33: arachidonate 15-lipoxygenase
EC 1.13.11.34: arachidonate 5-lipoxygenase
EC 1.13.11.35: pyrogallol 1,2-oxygenase
EC 1.13.11.36: chloridazon-catechol dioxygenase
EC 1.13.11.37: hydroxyquinol 1,2-dioxygenase
EC 1.13.11.38: 1-hydroxy-2-naphthoate 1,2-dioxygenase
EC 1.13.11.39: biphenyl-2,3-diol 1,2-dioxygenase
EC 1.13.11.40: arachidonate 8-lipoxygenase
EC 1.13.11.41: 2,4′-dihydroxyacetophenone dioxygenase
EC 1.13.11.42: [[identical to EC 1.13.11.11, tryptophan 2,3-dioxygenase]]
EC 1.13.11.43: lignostilbene αβ-dioxygenase
EC 1.13.11.44: [[Activity is covered by EC 1.13.11.60, linoleate 8R-lipoxygenase and EC 5.4.4.6, 9,12-octadecadienoate 8-hydroperoxide 8S-isomerase|Activity is covered by EC 1.13.11.60, linoleate 8R-lipoxygenase and EC 5.4.4.6, 9,12-octadecadienoate 8-hydroperoxide 8S-isomerase]]
EC 1.13.11.45: linoleate 11-lipoxygenase
EC 1.13.11.46: 4-hydroxymandelate synthase
EC 1.13.11.47: 3-hydroxy-4-oxoquinoline 2,4-dioxygenase
EC 1.13.11.48: 3-hydroxy-2-methyl-quinolin-4-one 2,4-dioxygenase
EC 1.13.11.49: chlorite O₂-lyase
EC 1.13.11.50: acetylacetone-cleaving enzyme
EC 1.13.11.51: 9-cis-epoxycarotenoid dioxygenase
EC 1.13.11.52: indoleamine 2,3-dioxygenase
EC 1.13.11.53: acireductone dioxygenase (Ni²⁺-requiring)
EC 1.13.11.54: acireductone dioxygenase [iron(II)-requiring]
EC 1.13.11.55: sulfur oxygenase/reductase
EC 1.13.11.56: 1,2-dihydroxynaphthalene dioxygenase
EC 1.13.11.57: gallate dioxygenase
EC 1.13.11.58: linoleate 9S-lipoxygenase
EC 1.13.11.59: torulene dioxygenase
EC 1.13.11.60: inoleate 8R-lipoxygenase
EC 1.13.11.61: linolenate 9R-lipoxygenase
EC 1.13.11.62: linoleate 10R-lipoxygenase
EC 1.13.11.63: β-carotene 15,15′-dioxygenase
EC 1.13.11.64: 5-nitrosalicylate dioxygenase
EC 1.13.11.65: carotenoid isomerooxygenase
EC 1.13.11.66: hydroquinone 1,2-dioxygenase
EC 1.13.11.67: 8′-apo-β-carotenoid 14′,13′-cleaving dioxygenase
EC 1.13.11.68: 9-cis-β-carotene 9′,10′-cleaving dioxygenase
EC 1.13.11.69: carlactone synthase
EC 1.13.11.70: all-trans-10′-apo-β-carotenal 13,14-cleaving dioxygenase
EC 1.13.11.71: carotenoid-9′,10′-cleaving dioxygenase
EC 1.13.11.72: 2-hydroxyethylphosphonate dioxygenase
EC 1.13.11.73: methylphosphonate synthase
EC 1.13.11.74: 2-aminophenol 1,6-dioxygenase
EC 1.13.11.75: all-trans-8′-apo-β-carotenal 15,15′-oxygenase
EC 1.13.11.76: 2-amino-5-chlorophenol 1,6-dioxygenase
EC 1.13.11.77: oleate 10S-lipoxygenase
EC 1.13.11.78: 2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming)
EC 1.13.11.79: aerobic 5,6-dimethylbenzimidazole synthase
EC 1.13.11.80: (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase
EC 1.13.11.81: 7,8-dihydroneopterin oxygenase
EC 1.13.11.82: 8′-apo-carotenoid 13,14-cleaving dioxygenase
EC 1.13.11.83: 4-hydroxy-3-prenylphenylpyruvate oxygenase
EC 1.13.11.84: crocetin dialdehyde synthase
EC 1.13.11.85: exo-cleaving rubber dioxygenase
EC 1.13.11.86: 5-aminosalicylate 1,2-dioxygenase
EC 1.13.11.87: endo-cleaving rubber dioxygenase
EC 1.13.11.88: isoeugenol monooxygenase
EC 1.13.11.89: (hydroxymethyl)phosphonate dioxygenase
EC 1.13.11.90: [1-hydroxy-2-(trimethylamino)ethyl]phosphonate dioxygenase (glycine-betaine-forming)
EC 1.13.11.91: 3-mercaptopropionate dioxygenase
EC 1.13.11.92: fatty acid α-dioxygenase

EC 1.13.12 With incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

EC 1.13.12.1: arginine 2-monooxygenase
EC 1.13.12.2: lysine 2-monooxygenase
EC 1.13.12.3: tryptophan 2-monooxygenase
EC 1.13.12.4: lactate 2-monooxygenase
EC 1.13.12.5: Renilla-type luciferase
EC 1.13.12.6: Cypridina-luciferin 2-monooxygenase
EC 1.13.12.7: firefly luciferase
EC 1.13.12.8: Watasenia-luciferin 2-monooxygenase
EC 1.13.12.9: phenylalanine 2-monooxygenase
EC 1.13.12.10: [[Reaction covered by EC 1.14.13.59, L-lysine 6-monooxygenase (NADPH)|Reaction covered by EC 1.14.13.59, L-lysine 6-monooxygenase (NADPH)]]
EC n1.13.12.11: [[The activity is due to EC 1.14.13.8, flavin-containing monooxygenase]]
EC 1.13.12.12: transferred to EC 1.13.11.67, 8-apo-β-carotenoid 14′,13′-cleaving dioxygenase
EC 1.13.12.13: Oplophorus-luciferin 2-monooxygenase
EC 1.13.12.14: Now EC 1.14.13.122, chlorophyllide-a oxygenase
EC 1.13.12.15: 3,4-dihydroxyphenylalanine oxidative deaminase
EC 1.13.12.16: nitronate monooxygenase
EC 1.13.12.17: dichloroarcyriaflavin A synthase
EC 1.13.12.18: dinoflagellate luciferase
EC 1.13.12.19: 2-oxoglutarate dioxygenase (ethene-forming)
EC 1.13.12.20: noranthrone monooxygenase
EC 1.13.12.21: tetracenomycin-F1 monooxygenase
EC 1.13.12.22: deoxynogalonate monooxygenase
EC 1.13.12.23: 4-hydroxy-3-prenylbenzoate synthase
EC 1.13.12.24: calcium-regulated photoprotein

EC 1.13.99 Miscellaneous

EC 1.13.99.1: inositol oxygenase
EC 1.13.99.2: Now EC 1.14.12.10, benzoate 1,2-dioxygenase
EC 1.13.99.3: tryptophan 2′-dioxygenase
EC 1.13.99.4: Now EC 1.14.12.9, 4-chlorophenylacetate 3,4-dioxygenase
EC 1.13.99.5: now EC 1.13.11.47, 3-hydroxy-4-oxoquinoline 2,4-dioxygenase

EC 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

EC 1.14.1 With NADH or NADPH as one donor (deleted sub-subclass)

EC 1.14.1.1: now EC 1.14.14.1, unspecific monooxygenase
EC 1.14.1.2: now EC 1.14.13.9, kynurenine 3-monooxygenase
EC 1.14.1.3: deleted, covered by EC 1.14.99.7, squalene monooxygenase and EC 5.4.99.7, lanosterol synthase
EC 1.14.1.4: now EC 1.14.99.2, kynurenine 7,8-hydroxylase
EC 1.14.1.5: now EC 1.14.13.5; imidazoleacetate 4-monooxygenase
EC 1.14.1.6: now EC 1.14.15.4, steroid 11β-monooxygenase
EC 1.14.1.7: now EC 1.14.99.9, steroid 17α-monooxygenase
EC 1.14.1.8: now EC 1.14.99.10, steroid 21-monooxygenase
EC 1.14.1.9: deleted
EC 1.14.1.10: now EC 1.14.99.11 estradiol 6β-monooxygenase
EC 1.14.1.11: deleted

EC 1.14.2 With ascorbate as one donor (deleted sub-subclass)

EC 1.14.2.1: now EC 1.14.17.1, dopamine β-monooxygenase
EC 1.14.2.2: now EC 1.13.11.27, 4-hydroxyphenylpyruvate dioxygenase

EC 1.14.3 With reduced pteridine as one donor (deleted sub-subclass)

EC 1.14.3.1: now EC 1.14.16.1, phenylalanine 4-monooxygenase

EC 1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

EC 1.14.11.1: γ-butyrobetaine dioxygenase
EC 1.14.11.2: procollagen-proline dioxygenase
EC 1.14.11.3: pyrimidine-deoxynucleoside 2′-dioxygenase
EC 1.14.11.4: procollagen-lysine 5-dioxygenase
EC 1.14.11.5: Now included with EC 1.14.11.6 thymine dioxygenase
EC 1.14.11.6: thymine dioxygenase
EC 1.14.11.7: procollagen-proline 3-dioxygenase
EC 1.14.11.8: trimethyllysine dioxygenase
EC 1.14.11.9: flavanone 3-dioxygenase
EC 1.14.11.10: pyrimidine-deoxynucleoside 1′-dioxygenase
EC 1.14.11.11: hyoscyamine (6S)-dioxygenase
EC 1.14.11.12: gibberellin-44 dioxygenase
EC 1.14.11.13: gibberellin 2β-dioxygenase
EC 1.14.11.14: Now EC 1.14.20.13, 6β-hydroxyhyoscyamine epoxidase
EC 1.14.11.15: gibberellin 3β-dioxygenase
EC 1.14.11.16: peptide-aspartate β-dioxygenase
EC 1.14.11.17: taurine dioxygenase
EC 1.14.11.18: phytanoyl-CoA dioxygenase
EC 1.14.11.19: Now EC 1.14.20.4, anthocyanidin synthase
EC 1.14.11.20: deacetoxyvindoline 4-hydroxylase
EC 1.14.11.21: clavaminate synthase
EC 1.14.11.22: Now EC 1.14.20.5, flavone synthase
EC 1.14.11.23: Now EC 1.14.20.6, flavonol synthase
EC 1.14.11.24: 2′-deoxymugineic-acid 2′-dioxygenase
EC 1.14.11.25: mugineic-acid 3-dioxygenase
EC 1.14.11.26: deacetoxycephalosporin-C hydroxylase
EC 1.14.11.27: [histone H3]-dimethyl-L-lysine³⁶ demethylase
EC 1.14.11.28: proline 3-hydroxylase
EC 1.14.11.29: hypoxia-inducible factor-proline dioxygenase
EC 1.14.11.30: hypoxia-inducible factor-asparagine dioxygenase
EC 1.14.11.31: thebaine 6-O-demethylase
EC 1.14.11.32: codeine 3-O-demethylase
EC 1.14.11.33: DNA oxidative demethylase
EC 1.14.11.34: Now EC 1.14.20.7, 2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming)
EC 1.14.11.35: 1-deoxypentalenic acid 11β-hydroxylase
EC 1.14.11.36: pentalenolactone F synthase
EC 1.14.11.36: pentalenolactone F synthase
EC 1.14.11.37: kanamycin B dioxygenase
EC 1.14.11.38: verruculogen synthase
EC 1.14.11.39: L-asparagine hydroxylase
EC 1.14.11.40: enduracididine β-hydroxylase
EC 1.14.11.41: L-arginine hydroxylase
EC 1.14.11.42: tRNA^Phe (7-(3-amino-3-carboxypropyl)wyosine³⁷-C²)-hydroxylase
EC 1.14.11.43: (S)-dichlorprop dioxygenase (2-oxoglutarate)
EC 1.14.11.44: (R)-dichlorprop dioxygenase (2-oxoglutarate)
EC 1.14.11.45: L-isoleucine 4-hydroxylase
EC 1.14.11.46: 2-aminoethylphosphonate dioxygenase
EC 1.14.11.47: [50S ribosomal protein L16]-arginine 3-hydroxylase
EC 1.14.11.48: xanthine dioxygenase
EC 1.14.11.49: uridine-5′-phosphate dioxygenase
EC|1.14.11.50: Now EC 1.14.20.8, (–)-deoxypodophyllotoxin synthase
EC 1.14.11.51: DNA N⁶-methyladenine demethylase
EC 1.14.11.52: validamycin A dioxygenase
EC 1.14.11.53: mRNA N⁶-methyladenine demethylase
EC 1.14.11.54: mRNA N¹-methyladenine demethylase
EC 1.14.11.55: ectoine hydroxylase
EC 1.14.11.56: L-proline cis-4-hydroxylase
EC 1.14.11.57: L-proline trans-4-hydroxylase
EC 1.14.11.58: ornithine lipid ester-linked acyl 2-hydroxylase
EC 1.14.11.59: 2,4-dihydroxy-1,4-benzoxazin-3-one-glucoside dioxygenase
EC 1.14.11.60: scopoletin 8-hydroxylase
EC 1.14.11.61: feruloyl-CoA 6-hydroxylase
EC 1.14.11.62: trans-4-coumaroyl-CoA 2-hydroxylase
EC 1.14.11.63: peptidyl-lysine (3S)-dioxygenase
EC 1.14.11.64: glutarate dioxygenase
EC 1.14.11.65: [histone H3]-dimethyl-L-lysine⁹ demethylase
EC 1.14.11.66: [histone H3]-trimethylL-lysine⁹ demethylase
EC 1.14.11.67: [histone H3]-trimethyl-LL-lysine⁴ demethylase
EC 1.14.11.68: [histone H3]-trimethyl-L-lysine²⁷ demethylase
EC 1.14.11.69: [histone H3]-trimethyl-L-lysine³⁷ demethylase
EC 1.14.11.70: 7-deoxycylindrospermopsin hydroxylase
EC 1.14.11.71: methylphosphonate hydroxylase
EC 1.14.11.72: [2-(trimethylamino)ethyl]phosphonate dioxygenase
EC 1.14.11.73: [protein]-arginine 3-hydroxylase
EC 1.14.11.74: L-isoleucine 3¹-dioxygenase
EC 1.14.11.75: 3¹-hydroxy-L-isoleucine 4-dioxygenase
EC 1.14.11.76: L-glutamate 3(R)-hydroxylase
EC 1.14.11.77: alkyl sulfatase

EC 1.14.12 With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

EC 1.14.12.1: anthranilate 1,2-dioxygenase (deaminating, decarboxylating)
EC 1.14.12.2: Now EC 1.14.13.35 anthranilate 3-monooxygenase (deaminating)
EC 1.14.12.3: benzene 1,2-dioxygenase
EC 1.14.12.4: [[EC 1.14.13.242, 3-hydroxy-2-methylpyridinecarboxylate monooxygenase]]
EC 1.14.12.5: Now EC .14.13.241, 5-pyridoxate monooxygenase
EC 1.14.12.6: Now EC 1.14.13.66, 2-hydroxycyclohexanone 2-monooxygenase
EC 1.14.12.7: phthalate 4,5-dioxygenase
EC 1.14.12.8: 4-sulfobenzoate 3,4-dioxygenase
EC 1.14.12.9: 4-chlorophenylacetate 3,4-dioxygenase
EC 1.14.12.10: benzoate 1,2-dioxygenase
EC 1.14.12.11: toluene dioxygenase
EC 1.14.12.12: naphthalene 1,2-dioxygenase
EC 1.14.12.13: 2-halobenzoate 1,2-dioxygenase
EC 1.14.12.14: 2-aminobenzenesulfonate 2,3-dioxygenase
EC 1.14.12.15: terephthalate 1,2-dioxygenase
EC 1.14.12.16: 2-hydroxyquinoline 5,6-dioxygenase
EC 1.14.12.17: nitric oxide dioxygenase
EC 1.14.12.18: biphenyl 2,3-dioxygenase
EC 1.14.12.19: 3-phenylpropionate dioxygenase
EC 1.14.12.20: Now classified as EC 1.14.15.17, pheophorbide a oxygenase.
EC 1.14.12.21: Now EC 1.14.13.208, benzoyl-CoA 2,3-epoxidase
EC 1.14.12.22: carbazole 1,9a-dioxygenase
EC 1.14.12.23: nitroarene dioxygenase
EC 1.14.12.24: 2,4-dinitrotoluene dioxygenase
EC 1.14.12.25: p-cumate 2,3-dioxygenase
EC 1.14.12.26: chlorobenzene dioxygenase

EC 1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

EC 1.14.13.1: salicylate 1-monooxygenase
EC 1.14.13.2: 4-hydroxybenzoate 3-monooxygenase
EC 1.14.13.3: Now EC 1.14.14.9, 4-hydroxyphenylacetate 3-monooxygenase
EC 1.14.13.4: melilotate 3-monooxygenase
EC 1.14.13.5: imidazoleacetate 4-monooxygenase
EC 1.14.13.6: orcinol 2-monooxygenase
EC 1.14.13.7: phenol 2-monooxygenase
EC 1.14.13.8: flavin-containing monooxygenase
EC 1.14.13.9: kynurenine 3-monooxygenase
EC 1.14.13.10: 2,6-dihydroxypyridine 3-monooxygenase
EC 1.14.13.11: Now EC 1.14.14.91, trans-cinnamate 4-monooxygenase
EC 1.14.13.12: Now EC 1.14.14.92, benzoate 4-monooxygenase
EC 1.14.13.13: Now classified as EC 1.14.15.18, calcidiol 1-monooxygenase
EC 1.14.13.14: trans-cinnamate 2-monooxygenase
EC 1.14.13.15: Now EC 1.14.15.15, cholestanetriol 26-monooxygenase
EC 1.14.13.16: cyclopentanone monooxygenase
EC 1.14.13.17: Now EC 1.14.14.23, cholesterol 7α-monooxygenase
EC 1.14.13.18: 4-hydroxyphenylacetate 1-monooxygenase
EC 1.14.13.19: taxifolin 8-monooxygenase
EC 1.14.13.20: 2,4-dichlorophenol 6-monooxygenase
EC 1.14.13.21: Now EC 1.14.14.82, flavonoid 3′-monooxygenase
EC 1.14.13.22: cyclohexanone monooxygenase
EC 1.14.13.23: 3-hydroxybenzoate 4-monooxygenase
EC 1.14.13.24: 3-hydroxybenzoate 6-monooxygenase
EC 1.14.13.25: methane monooxygenase (soluble)
EC 1.14.13.26: Now classified as EC 1.14.18.4, phosphatidylcholine 12-monooxygenase
EC 1.14.13.27: 4-aminobenzoate 1-monooxygenase
EC 1.14.13.28: Now EC 1.14.14.93, 3,9-dihydroxypterocarpan 6a-monooxygenase
EC 1.14.13.29: 4-nitrophenol 2-monooxygenase
EC 1.14.13.30: Now EC 1.14.14.94, leukotriene-B₄ 20-monooxygenase
EC 1.14.13.31: 2-nitrophenol 2-monooxygenase
EC 1.14.13.32: albendazole monooxygenase
EC 1.14.13.33: 4-hydroxybenzoate 3-monooxygenase (NAD(P)H)
EC 1.14.13.34: leukotriene-E₄ 20-monooxygenase
EC 1.14.13.35: anthranilate 3-monooxygenase (deaminating)
EC 1.14.13.36: Now EC 1.14.14.96, 5-O-(4-coumaroyl)-D-quinate 3′-monooxygenase
EC 1.14.13.37: Now EC 1.14.14.97, methyltetrahydroprotoberberine 14-monooxygenase
EC 1.14.13.38: anhydrotetracycline monooxygenase
EC 1.14.13.39: nitric-oxide synthase
EC 1.14.13.40: anthraniloyl-CoA monooxygenase
EC 1.14.13.41: Now EC 1.14.14.36, tyrosine N-monooxygenase
EC 1.14.13.42: [[The activity is covered by EC 1.14.13.68, 4-hydroxyphenylacetaldehyde oxime monooxygenase]]
EC 1.14.13.43: questin monooxygenase
EC 1.14.13.44: 2-hydroxybiphenyl 3-monooxygenase
EC 1.14.13.45: Now EC 1.14.18.2, CMP-N-acetylneuraminate monooxygenase
EC 1.14.13.46: (-)-menthol monooxygenase
EC 1.14.13.47: Now EC 1.14.14.99, (S)-limonene 3-monooxygenase
EC 1.14.13.48: Now classified as EC 1.14.14.51, (S)-limonene 6-monooxygenase
EC 1.14.13.49: Now classified as EC 1.14.14.52, (S)-limonene 7-monooxygenase
EC 1.14.13.50: pentachlorophenol monooxygenase
EC 1.14.13.51: 6-oxocineole dehydrogenase
EC 1.14.13.52: Now EC 1.14.14.88, isoflavone 3′-hydroxylase
EC 1.14.13.53: Now EC 1.14.14.89, 4′-methoxyisoflavone 2′-hydroxylase
EC 1.14.13.54: ketosteroid monooxygenase
EC 1.14.13.55: Now EC 1.14.14.98, protopine 6-monooxygenase
EC 1.14.13.56: Now EC 1.14.14.100, dihydrosanguinarine 10-monooxygenase
EC 1.14.13.57: Now EC 1.14.14.101, dihydrochelirubine 12-monooxygenase
EC 1.14.13.58: benzoyl-CoA 3-monooxygenase
EC 1.14.13.59: L-lysine N⁶-monooxygenase (NADPH)
EC 1.14.13.60: Now included with EC 1.14.13.100, 25-hydroxycholesterol 7α-hydroxylase
EC 1.14.13.61: 2-hydroxyquinoline 8-monooxygenase
EC 1.14.13.62: 4-hydroxyquinoline 3-monooxygenase
EC 1.14.13.63: 3-hydroxyphenylacetate 6-hydroxylase
EC 1.14.13.64: 4-hydroxybenzoate 1-hydroxylase
EC 1.14.13.65: deleted
EC 1.14.13.66: 2-hydroxycyclohexanone 2-monooxygenase
EC 1.14.13.67: Now EC 1.14.14.55, quinine 3-monooxygenase
EC 1.14.13.68: Now EC 1.14.14.37, 4-hydroxyphenylacetaldehyde oxime monooxygenase
EC 1.14.13.69: alkene monooxygenase
EC 1.14.13.70: Now EC 1.14.14.154, sterol 14α-demethylase
EC 1.14.13.71: Now EC 1.14.14.102, N-methylcoclaurine 3′-monooxygenase
EC 1.14.13.72: Now classified as EC 1.14.18.9, methylsterol monooxygenase
EC 1.14.13.73: Now EC 1.14.14.103, tabersonine 16-hydroxylase
EC 1.14.13.74: Now EC 1.14.14.85, 7-deoxyloganin 7-hydroxylase
EC 1.14.13.75: Now EC 1.14.14.104, vinorine hydroxylase
EC 1.14.13.76: Now EC 1.14.14.105, taxane 10β-hydroxylase
EC 1.14.13.77: Now EC 1.14.14.106, taxane 13α-hydroxylase
EC 1.14.13.78: Now EC 1.14.14.86, ent-kaurene monooxygenase
EC 1.14.13.79: Now EC 1.14.14.107, ent-kaurenoic acid oxidase
EC 1.14.13.80: Now classified as EC 1.14.14.53, (R)-limonene 6-monooxygenase
EC 1.14.13.81: magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase
EC 1.14.13.82: vanillate monooxygenase
EC 1.14.13.83: precorrin-3B synthase
EC 1.14.13.84: 4-hydroxyacetophenone monooxygenase
EC 1.14.13.85: Now EC 1.14.14.135, glyceollin synthase
EC 1.14.13.86: [[The activity is covered by EC 1.14.14.87, 2-hydroxyisoflavanone synthase]]
EC 1.14.13.87: Now EC 1.14.14.140, licodione synthase]
EC 1.14.13.88: Now EC 1.14.14.81, flavanoid 3,5-hydroxylase
EC 1.14.13.89: Now EC 1.14.14.90, isoflavone 2-hydroxylase
EC 1.14.13.90: Now EC 1.14.15.21, zeaxanthin epoxidase
EC 1.14.13.91: Now EC 1.14.14.136, deoxysarpagine hydroxylase
EC 1.14.13.92: phenylacetone monooxygenase
EC 1.14.13.93: Now EC 1.14.14.137, (+)-abscisic acid 8-hydroxylase
EC 1.14.13.94: Now EC 1.14.14.138, lithocholate 6β-hydroxylase
EC 1.14.13.95: Now included with EC 1.14.14.139, 5β-cholestane-3α,7α-diol 12α-hydroxylase
EC 1.14.13.96: Now EC 1.14.14.139, 5β-cholestane-3α,7α-diol 12α-hydroxylase
EC 1.14.13.97: Now EC 1.14.14.57, taurochenodeoxycholate 6α-hydroxylase
EC 1.14.13.98: Now EC 1.14.14.25, cholesterol 24-hydroxylase
EC 1.14.13.99: Now EC 1.14.14.26, 24-hydroxycholesterol 7α-hydroxylase
EC 1.14.13.100: Now classified as EC 1.14.14.29, 25/26-hydroxycholesterol 7α-hydroxylase
EC 1.14.13.101: senecionine N-oxygenase
EC 1.14.13.102: Now EC 1.14.14.141, psoralen synthase
EC 1.14.13.103: Now EC 1.14.14.142, 8-dimethylallylnaringenin 2-hydroxylase
EC 1.14.13.104: Now EC 1.14.14.143, (+)-menthofuran synthase
EC 1.14.13.105: monocyclic monoterpene ketone monooxygenase
EC 1.14.13.106: now classified as EC 1.14.15.39, epi-isozizaene 5-monooxygenase.
EC 1.14.13.107: limonene 1,2-monooxygenase
EC 1.14.13.108: Now EC 1.14.14.144, abieta-7,13-diene hydroxylase
EC 1.14.13.109: Now EC 1.14.14.145, abieta-7,13-dien-18-ol hydroxylase
EC 1.14.13.110: Now EC 1.14.14.146, geranylgeraniol 18-hydroxylase
EC 1.14.13.111: methanesulfonate monooxygenase
EC 1.14.13.112: Now EC 1.14.14.147, 3-epi-6-deoxocathasterone 23-monooxygenase
EC 1.14.13.113: FAD-dependent urate hydroxylase
EC 1.14.13.114: 6-hydroxynicotinate 3-monooxygenase
EC 1.14.13.115: Now EC 1.14.14.148, angelicin synthase
EC 1.14.13.116: Now EC 1.14.14.174, geranylhydroquinone 3-hydroxylase
EC 1.14.13.117: Now EC 1.14.14.39, isoleucine N-monooxygenase
EC 1.14.13.118: Now EC 1.14.14.38, valine N-monooxygenase
EC 1.14.13.119: Now EC 1.14.14.149, 5-epiaristolochene 1,3-dihydroxylase
EC 1.14.13.120: Now EC 1.14.14.150, costunolide synthase
EC 1.14.13.121: Now EC 1.14.14.151, premnaspirodiene oxygenase
EC 1.14.13.122: chlorophyllide-a oxygenase
EC 1.14.13.123: Now EC 1.14.14.95, germacrene A hydroxylase
EC 1.14.13.124: now classified as EC 1.14.14.40, phenylalanine N-monooxygenase
EC 1.14.13.125: Now EC 1.14.14.156, tryptophan N-monooxygenase
EC 1.14.13.126: Now EC 1.14.15.16, vitamin D₃ 24-hydroxylase
EC 1.14.13.127: 3-(3-hydroxyphenyl)propanoate hydroxylase
EC 1.14.13.128: 7-methylxanthine demethylase
EC 1.14.13.129: Now EC 1.14.15.24, β-carotene 3-hydroxylase
EC 1.14.13.130: pyrrole-2-carboxylate monooxygenase
EC 1.14.13.131: dimethyl-sulfide monooxygenase
EC 1.14.13.132: Now EC 1.14.14.17, squalene monooxygenase
EC 1.14.13.133: Now EC 1.14.15.32, pentalenene oxygenase
EC 1.14.13.134: Now EC 1.14.14.152, β-amyrin 11-oxidase
EC 1.14.13.135: 1-hydroxy-2-naphthoate hydroxylase
EC 1.14.13.136: Now EC 1.14.14.87, 2-hydroxyisoflavanone synthase
EC 1.14.13.137: Now EC 1.14.14.153, indole-2-monooxygenase
EC 1.14.13.138: Now EC 1.14.14.157, indolin-2-one monooxygenase
EC 1.14.13.139: Now EC 1.14.14.109, 3-hydroxyindolin-2-one monooxygenase
EC 1.14.13.140: Now EC 1.14.14.110, 2-hydroxy-1,4-benzoxazin-3-one monooxygenase.
EC 1.14.13.141: Now EC 1.14.15.29, cholest-4-en-3-one 26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming]
EC 1.14.13.142: Now EC 1.14.15.30, 3-ketosteroid 9α-monooxygenase
EC 1.14.13.143: Now EC 1.14.14.76 ent-isokaurene C2/C3-hydroxylase
EC 1.14.13.144: Now EC 1.14.14.111, 9β-pimara-7,15-diene oxidase
EC 1.14.13.145: Now EC 1.14.14.112, ent-cassa-12,15-diene 11-hydroxylase
EC 1.14.13.146: taxoid 14β-hydroxylase
EC 1.14.13.147: taxoid 7β-hydroxylase
EC 1.14.13.148: trimethylamine monooxygenase
EC 1.14.13.149: phenylacetyl-CoA 1,2-epoxidase
EC 1.14.13.150: Now EC 1.14.14.113, α-humulene 10-hydroxylase
EC 1.14.13.151: Now EC 1.14.14.84, linalool 8-monooxygenase
EC 1.14.13.152: Now EC 1.14.14.83, geraniol 8-hydroxylase
EC 1.14.13.153: (+)-sabinene 3-hydroxylase
EC 1.14.13.154: erythromycin 12-hydroxylase
EC 1.14.13.155: α-pinene monooxygenase
EC 1.14.13.156: Now EC 1.14.14.133, 1,8-cineole 2-endo-monooxygenase
EC 1.14.13.157: Now EC 1.14.14.56, 1,8-cineole 2-exo-monooxygenase
EC 1.14.13.158: Now EC 1.14.14.114, amorpha-4,11-diene 12-monooxygenase
EC 1.14.13.159: Now EC 1.14.14.24, vitamin D 25-hydroxylase
EC 1.14.13.160: (2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA 1,5-monooxygenase
EC 1.14.13.161: (+)-camphor 6-exo-hydroxylase
EC 1.14.13.162: Now EC 1.14.14.108, 2,5-diketocamphane 1,2-monooxygenase
EC 1.14.13.163: 6-hydroxy-3-succinoylpyridine 3-monooxygenase
EC 1.14.13.164: [[withdrawn: see EC 1.13.11.65, carotenoid isomerooxygenase]]
EC 1.14.13.165: Now classified as EC 1.14.14.47, nitric-oxide synthase (flavodoxin)
EC 1.14.13.166: 4-nitrocatechol 4-monooxygenase
EC 1.14.13.167: 4-nitrophenol 4-monooxygenase
EC 1.14.13.168: indole-3-pyruvate monooxygenase
EC 1.14.13.169: Now EC 1.14.18.5, sphingolipid C4-monooxygenase
EC 1.14.13.170: pentalenolactone D synthase
EC 1.14.13.171: neopentalenolactone D synthase
EC 1.14.13.172: salicylate 5-hydroxylase
EC 1.14.13.173: Now EC 1.14.14.115, 11-oxo-β-amyrin 30-oxidase
EC 1.14.13.174: Now EC 1.14.14.116, averantin hydroxylase
EC 1.14.13.175: Now EC 1.14.14.117, aflatoxin B synthase
EC 1.14.13.176: Now EC 1.14.14.118, tryprostatin B 6-hydroxylase
EC 1.14.13.177: Now EC 1.14.14.119, fumitremorgin C monooxygenase
EC 1.14.13.178: methylxanthine N¹-demethylase
EC 1.14.13.179: methylxanthine N³-demethylase
EC 1.14.13.180: aklavinone 12-hydroxylase
EC 1.14.13.181: 13-deoxydaunorubicin hydroxylase
EC 1.14.13.182: 2-heptyl-3-hydroxy-4(1H)-quinolone synthase
EC 1.14.13.183: Now EC 1.14.14.120, dammarenediol 12-hydroxylase
EC 1.14.13.184: Now EC 1.14.14.121, protopanaxadiol 6-hydroxylase
EC 1.14.13.185: Now EC 1.14.15.33, pikromycin synthase
EC 1.14.13.186: Now EC 1.14.15.34, 20-oxo-5-O-mycaminosyltylactone 23-monooxygenase
EC 1.14.13.187: L-evernosamine nitrososynthase
EC 1.14.13.188: Now EC 1.14.15.35, 6-deoxyerythronolide B hydroxylase
EC 1.14.13.189: 5-methyl-1-naphthoate 3-hydroxylase
EC 1.14.13.190: Now EC 1.14.14.175, ferruginol synthase
EC 1.14.13.191: Now EC 1.14.14.70, ent-sandaracopimaradiene 3-hydroxylase
EC 1.14.13.192: Now EC 1.14.14.122, oryzalexin E synthase
EC 1.14.13.193: Now EC 1.14.14.123, oryzalexin D synthase
EC 1.14.13.194: Now EC 1.14.14.78, phylloquinone ω-hydroxylase
EC 1.14.13.195: L-ornithine N⁵-monooxygenase (NADPH)
EC 1.14.13.196: L-ornithine N⁵-monooxygenase [NAD(P)H]
EC 1.14.13.197: Now EC 1.14.14.124, dihydromonacolin L hydroxylase
EC 1.14.13.198: Now EC 1.14.14.125, monacolin L hydroxylase
EC 1.14.13.199: Now EC 1.14.14.79, docosahexaenoic acid ω-hydroxylase
EC 1.14.13.200: tetracenomycin A2 monooxygenase-dioxygenase
EC 1.14.13.201: Now EC 1.14.14.126, β-amyrin 28-monooxygenase
EC 1.14.13.202: Now EC 1.14.14.127, methyl farnesoate epoxidase
EC 1.14.13.203: Now EC 1.14.14.128, farnesoate epoxidase
EC 1.14.13.204: Now EC 1.14.14.129, long-chain acyl-CoA ω-monooxygenase
EC 1.14.13.205: Now EC 1.14.14.80, long-chain fatty acid ω-monooxygenase
EC 1.14.13.206: Now EC 1.14.14.130, laurate 7-monooxygenase
EC 1.14.13.207: Now EC 1.14.14.31, ipsdienol synthase
EC 1.14.13.208: benzoyl-CoA 2,3-epoxidase
EC 1.14.13.209: salicyloyl-CoA 5-hydroxylase
EC 1.14.13.210: 4-methyl-5-nitrocatechol 5-monooxygenase
EC 1.14.13.211: rifampicin monooxygenase
EC 1.14.13.212: 1,3,7-trimethyluric acid 5-monooxygenase
EC 1.14.13.213: Now EC 1.14.14.131, bursehernin 5-monooxygenase
EC 1.14.13.214: Now EC 1.14.14.132, (–)-4′-demethyl-deoxypodophyllotoxin 4-hydroxylase
EC 1.14.13.215: protoasukamycin 4-monooxygenase
EC 1.14.13.216: asperlicin C monooxygenase
EC 1.14.13.217: protodeoxyviolaceinate monooxygenase
EC 1.14.13.218: 5-methylphenazine-1-carboxylate 1-monooxygenase
EC 1.14.13.219: resorcinol 4-hydroxylase (NADPH)
EC 1.14.13.220: resorcinol 4-hydroxylase (NADH)
EC 1.14.13.221: Now EC 1.14.15.28, cholest-4-en-3-one 26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming]
EC 1.14.13.222: aurachin C monooxygenase/isomerase
EC 1.14.13.223: 3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] 5-monooxygenase
EC 1.14.13.224: violacein synthase
EC 1.14.13.225: F-actin monooxygenase
EC 1.14.13.226: acetone monooxygenase (methyl acetate-forming)
EC 1.14.13.227: propane 2-monooxygenase
EC 1.14.13.228: jasmonic acid 12-hydroxylase
EC 1.14.13.229: tert-butyl alcohol monooxygenase
EC 1.14.13.230: butane monooxygenase (soluble)
EC 1.14.13.231: tetracycline 11a-monooxygenase
EC 1.14.13.232: 6-methylpretetramide 4-monooxygenase
EC 1.14.13.233: 4-hydroxy-6-methylpretetramide 12a-monooxygenase
EC 1.14.13.234: 5a,11a-dehydrotetracycline 5-monooxygenase
EC 1.14.13.235: indole-3-acetate monooxygenase
EC 1.14.13.236: toluene 4-monooxygenase
EC 1.14.13.237: aliphatic glucosinolate S-oxygenase
EC 1.14.13.238: dimethylamine monooxygenase
EC 1.14.13.239: carnitine monooxygenase
EC 1.14.13.240: 2-polyprenylphenol 6-hydroxylase
EC 1.14.13.241: 5-pyridoxate monooxygenase
EC 1.14.13.242: 3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase
EC 1.14.13.243: toluene 2-monooxygenase
EC 1.14.13.244: phenol 2-monooxygenase (NADH)
EC 1.14.13.245: assimilatory dimethylsulfide S-monooxygenase
EC 1.14.13.246: 4β-methylsterol monooxygenase
EC 1.14.13.247: stachydrine N-demethylase

EC 1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

EC 1.14.15 With reduced iron–sulfur protein as one donor, and incorporation of one atom of oxygen

EC 1.14.15.1: camphor 5-monooxygenase
EC 1.14.15.2: Now EC 1.14.13.162, 2,5-diketocamphane 1,2-monooxygenase.
EC 1.14.15.3: alkane 1-monooxygenase
EC 1.14.15.4: steroid 11β-monooxygenase
EC 1.14.15.5: corticosterone 18-monooxygenase
EC 1.14.15.6: cholesterol monooxygenase (side-chain-cleaving)
EC 1.14.15.7: choline monooxygenase
EC 1.14.15.8: steroid 15β-monooxygenase
EC 1.14.15.9: spheroidene monooxygenase
EC 1.14.15.10: (+)-camphor 6-endo-hydroxylase
EC 1.14.15.11: pentalenic acid synthase
EC 1.14.15.12 : pimeloyl-[acyl-carrier protein] synthase. Now EC 1.14.14.46, pimeloyl-[acyl-carrier protein] synthase
EC 1.14.15.13: pulcherriminic acid synthase
EC 1.14.15.14: methyl-branched lipid ω-hydroxylase
EC 1.14.15.15: cholestanetriol 26-monooxygenase
EC 1.14.15.16: vitamin D₃ 24-hydroxylase
EC 1.14.15.17: pheophorbide a oxygenase
EC 1.14.15.18: calcidiol 1-monooxygenase
EC 1.14.15.19: C-19 steroid 1α-hydroxylase
EC 1.14.15.20: heme oxygenase (biliverdin-producing, ferredoxin)
EC 1.14.15.21: zeaxanthin epoxidase
EC 1.14.15.22: vitamin D 1,25-hydroxylase
EC 1.14.15.23: chloroacetanilide N-alkylformylase
EC 1.14.15.24: β-carotene 3-hydroxylase
EC 1.14.15.25: p-cymene methyl-monooxygenase
EC 1.14.15.26: toluene methyl-monooxygenase
EC 1.14.15.27: β-dihydromenaquinone-9 ω-hydroxylase
EC 1.14.15.28: cholest-4-en-3-one 26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming]
EC 1.14.15.29: cholest-4-en-3-one 26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming]
EC 1.14.15.30: 3-ketosteroid 9α-monooxygenase
EC 1.14.15.31: 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase
EC 1.14.15.32: pentalenene oxygenase
EC 1.14.15.33: pikromycin synthase
EC 1.14.15.34: 20-oxo-5-O-mycaminosyltylactone 23-monooxygenase
EC 1.14.15.35: 6-deoxyerythronolide B hydroxylase
EC 1.14.15.36: sterol 14α-demethylase (ferredoxin)
EC 1.14.15.37: luteothin monooxygenase
EC 1.14.15.38: N,N-dimethyl phenylurea N-demethylase
EC 1.14.15.39: epi-isozizaene 5-monooxygenase

EC 1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor

EC 1.14.17 With reduced ascorbate as one donor, and incorporation of one atom of oxygen into the other donor

EC 1.14.17.1: dopamine β-monooxygenase
EC |1.14.17.2: deleted, now included with EC 1.14.18.1 monophenol monooxygenase
EC 1.14.17.3: peptidylglycine monooxygenase
EC 1.14.17.4: aminocyclopropanecarboxylate oxidase

EC 1.14.18 With another compound as one donor, and incorporation of one atom of oxygen into the other donor

EC 1.14.18.1: tyrosinase
EC 1.14.18.2: CMP-N-acetylneuraminate monooxygenase
EC 1.14.18.3: methane monooxygenase (particulate)
EC 1.14.18.4: phosphatidylcholine 12-monooxygenase
EC 1.14.18.5: sphingolipid C4-monooxygenase
EC 1.14.18.6: 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase
EC 1.14.18.7: dihydroceramide fatty acyl 2-hydroxylase
EC 1.14.18.8: Now included with EC 1.14.14.139, 5β-cholestane-3α,7α-diol 12α-hydroxylase
EC 1.14.18.9: 4α-methylsterol monooxygenase
EC 1.14.18.10: plant 4,4-dimethylsterol C-4α-methyl-monooxygenase
EC 1.14.18.11: plant 4α-monomethylsterol monooxygenase
EC 1.14.18.12: 2-hydroxy fatty acid dioxygenase

EC 1.14.19 With oxidation of a pair of donors resulting in the reduction of O₂ to two molecules of water

EC 1.14.20 With 2-oxoglutarate as one donor, and the other dehydrogenated

EC 1.14.20.1: deacetoxycephalosporin-C synthase
EC 1.14.20.2: Now EC 1.14.11.59, 2,4-dihydroxy-1,4-benzoxazin-3-one-glucoside dioxygenase
EC 1.14.20.3: (5R)-carbapenem-3-carboxylate synthase
EC 1.14.20.4: anthocyanidin synthase
EC 1.14.20.5: flavone synthase I
EC 1.14.20.6: flavonol synthase
EC 1.14.20.7: 2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming)
EC 1.14.20.8: (–)-deoxypodophyllotoxin synthase
EC 1.14.20.9: L-tyrosine isonitrile desaturase
EC 1.14.20.10: L-tyrosine isonitrile desaturase/decarboxylase
EC 1.14.20.11: 3-[(Z)-2-isocyanoethenyl]-1H-indole synthase
EC 1.14.20.12: 3-[(E)-2-isocyanoethenyl]-1H-indole synthase
EC 1.14.20.13: 6β-hydroxyhyoscyamine epoxidase
EC 1.14.20.14: hapalindole-type alkaloid chlorinase
EC 1.14.20.15: L-threonyl-[L-threonyl-carrier protein] 4-chlorinase

EC 1.14.21 With NADH or NADPH as one donor, and the other dehydrogenated

EC 1.14.21.1: Now EC 1.14.19.64, (S)-stylopine synthase
EC 1.14.21.2: Now EC 1.14.19.65, (S)-cheilanthifoline synthase
EC 1.14.21.3: Now EC 1.14.19.66, berbamunine synthase
EC 1.14.21.4: Now EC 1.14.19.67, salutaridine synthase
EC 1.14.21.5: Now EC 1.14.19.68, (S)-canadine synthase
EC 1.14.21.6: Now EC 1.14.19.20, Δ⁷-sterol 5(6)-desaturase
EC 1.14.21.7: Now EC 1.14.19.69, biflaviolin synthase
EC 1.14.21.8: Now EC 1.14.19.63, pseudobaptigenin synthase
EC 1.14.21.9: Now EC 1.14.19.70, mycocyclosin synthase *
EC 1.14.21.10: Now EC 1.14.19.71, fumitremorgin C synthase *
EC 1.14.21.11: Now EC 1.14.19.72, (–)-pluviatolide synthase *
EC 1.14.21.12: Now EC 1.14.19.73, (S)-nandinine synthase *

EC 1.14.99 Miscellaneous

EC 1.14.99.1: prostaglandin-endoperoxide synthase
EC 1.14.99.2: kynurenine 7,8-hydroxylase
EC 1.14.99.3: Now EC 1.14.14.18, heme oxygenase (biliverdin-producing)
EC 1.14.99.4: progesterone monooxygenase
EC 1.14.99.5: Now EC 1.14.19.1, stearoyl-CoA 9-desaturase
EC 1.14.99.6: Now EC 1.14.19.2, acyl-[acyl-carrier-protein] desaturase
EC 1.14.99.7: Transferred to EC 1.14.13.132, squalene monooxygenase
EC 1.14.99.8: Now included with EC 1.14.14.1 unspecific monooxygenase
EC 1.14.99.9: Now classified as EC 1.14.14.19, steroid 17α-monooxygenase
EC 1.14.99.10: Now EC 1.14.14.16, steroid 21-monooxygenase
EC 1.14.99.11: estradiol 6β-monooxygenase
EC 1.14.99.12: 4-androstene-3,17-dione monooxygenase
EC 1.14.99.13: Now EC 1.14.13.23, 3-hydroxybenzoate 4-monooxygenase
EC 1.14.99.14: progesterone 11α-monooxygenase
EC 1.14.99.15: 4-methoxybenzoate monooxygenase (O-demethylating)
EC 1.14.99.16: Now EC 1.14.13.72, methylsterol monooxygenase
EC 1.14.99.17: Now EC 1.14.16.5, glyceryl-ether monooxygenase
EC 1.14.99.18: deleted
EC 1.14.99.19: Now classified as EC 1.14.19.77, plasmanylethanolamine desaturase
EC 1.14.99.20: phylloquinone monooxygenase (2,3-epoxidizing)
EC 1.14.99.21: Latia-luciferin monooxygenase (demethylating)
EC 1.14.99.22: ecdysone 20-monooxygenase
EC 1.14.99.23: 3-hydroxybenzoate 2-monooxygenase
EC 1.14.99.24: steroid 9α-monooxygenase
EC 1.14.99.25: Now EC 1.14.19.3, linoleoyl-CoA desaturase
EC 1.14.99.26: 2-hydroxypyridine 5-monooxygenase
EC 1.14.99.27: Now classified as EC 1.17.3.4, juglone 3-monooxygenase
EC 1.14.99.28: Now EC 1.14.14.84, linalool 8-monooxygenase
EC 1.14.99.29: deoxyhypusine monooxygenase
EC 1.14.99.30: Now EC 1.3.5.6, 9,9′-dicis-ζ-carotene desaturase.
EC 1.14.99.31: Now classified as EC 1.14.19.24, myristoyl-CoA 11-(E) desaturase
EC 1.14.99.32: Now classified as EC 1.14.19.5, acyl-CoA 11-(Z)-desaturase
EC 1.14.99.33: Now EC 1.14.19.39, acyl-lipid Δ¹²-acetylenase
EC 1.14.99.34: monoprenyl isoflavone epoxidase
EC 1.14.99.35: thiophene-2-carbonyl-CoA monooxygenase
EC 1.14.99.36: Now classified as EC 1.13.11.63, β-carotene 15,15′-dioxygenase
EC 1.14.99.37: Now EC 1.14.14.176, taxadiene 5α-hydroxylase
EC 1.14.99.38: cholesterol 25-hydroxylase
EC 1.14.99.39: ammonia monooxygenase
EC 1.14.99.40: Now EC 1.13.11.79, 5,6-dimethylbenzimidazole synthase
EC 1.14.99.41: Now EC 1.13.11.75, all-trans-8′-apo-β-carotenal 15,15′-oxygenase
EC 1.14.99.42: Now EC 1.13.11.84, crocetin dialdehyde synthase
EC 1.14.99.43: Now EC 1.14.14.134, β-amyrin 24-hydroxylase
EC 1.14.99.44: diapolycopene oxygenase
EC 1.14.99.45: Now EC 1.14.14.158, carotene ε-monooxygenase
EC 1.14.99.46: pyrimidine oxygenase
EC 1.14.99.47: (+)-larreatricin hydroxylase
EC 1.14.99.48: heme oxygenase (staphylobilin-producing)
EC 1.14.99.49: Now EC 1.14.15.31, 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase
EC 1.14.99.50: γ-glutamyl hercynylcysteine S-oxide synthase
EC 1.14.99.51: hercynylcysteine S-oxide synthase
EC 1.14.99.52: L-cysteinyl-L-histidinylsulfoxide synthase
EC 1.14.99.53: lytic chitin monooxygenase
EC 1.14.99.54: lytic cellulose monooxygenase (C1-hydroxylating)
EC 1.14.99.55: lytic starch monooxygenase
EC 1.14.99.56: lytic cellulose monooxygenase (C4-dehydrogenating)
EC 1.14.99.57: heme oxygenase (mycobilin-producing)
EC 1.14.99.58: heme oxygenase (biliverdin-IX-β and δ-forming)
EC 1.14.99.59: tryptamine 4-monooxygenase
EC 1.14.99.60: 3-demethoxyubiquinol 3-hydroxylase
EC 1.14.99.61: cyclooctat-9-en-7-ol 5-monooxygenase
EC 1.14.99.62: cyclooctatin synthase
EC 1.14.99.63: β-carotene 4-ketolase
EC 1.14.99.64: zeaxanthin 4-ketolase
EC 1.14.99.65: 4-amino-L-phenylalanyl-[CmlP-peptidyl-carrier-protein] 3-hydroxylase
EC 1.14.99.66: [histone H3]-N⁶,N⁶-dimethyl-L-lysine⁴ FAD-dependent demethylase
EC 1.14.99.67: α-N-dichloroacetyl-p-aminophenylserinol N-oxygenase
EC 1.14.99.68: 4-aminobenzoate N-oxygenase
EC 1.14.99.69: tRNA 2-(methylsulfanyl)-N⁶-isopentenyladenosine³⁷ hydroxylase

EC 1.15 Acting on superoxide as acceptor

EC 1.15.1

EC 1.16 Oxidizing metal ions

EC 1.16.1 With NAD⁺ or NADP⁺ as acceptor

EC 1.16.1.1: mercury(II) reductase
EC 1.16.1.2: diferric-transferrin reductase
EC 1.16.1.3: deleted since no specific enzyme catalysing this activity has been identified
EC 1.16.1.4: cob(II)alamin reductase
EC 1.16.1.5: deleted since the enzyme the entry was based on was later shown to be EC 1.2.1.51, pyruvate dehydrogenase (NADP⁺).
EC 1.16.1.6: cyanocobalamin reductase (cyanide-eliminating)
EC 1.16.1.7: ferric-chelate reductase
EC 1.16.1.8: [methionine synthase] reductase
EC 1.16.1.9: ferric-chelate reductase (NADPH)
EC 1.16.1.10: ferric-chelate reductase [NAD(P)H]

EC 1.16.3 With oxygen as acceptor

EC 1.16.5 With a quinone or similar compound as acceptor

EC 1.16.5.1: Now EC 7.2.1.3, ascorbate ferrireductase (transmembrane)

EC 1.16.8 With a flavin as acceptor

EC 1.16.8.1: activity now known to be catalyzed by EC 2.5.1.17, corrinoid adenosyltransferase

EC 1.16.9 With a copper protein as acceptor

EC 1.16.9.1: iron:rusticyanin reductase

EC 1.16.98 With other, known, physiological acceptors

EC 1.16.98.1: Now EC 1.16.9.1 iron:rusticyanin reductase

EC 1.16.99 With unknown physiological acceptors

EC 1.16.99.1: [Co(II) methylated amine-specific corrinoid protein] reductase

EC 1.17 Acting on CH or CH₂ groups

EC 1.17.1 With NAD or NADP as acceptor

EC 1.17.1.1: CDP-4-dehydro-6-deoxyglucose reductase
EC 1.17.1.2: now classified as EC 1.17.7.4, 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
EC 1.17.1.3: leucoanthocyanidin reductase
EC 1.17.1.4: xanthine dehydrogenase
EC 1.17.1.5: nicotinate dehydrogenase
EC 1.17.1.6: Now EC 1.17.99.5, bile-acid 7α-dehydroxylase. It is now known that FAD is the acceptor and not NAD⁺ as was thought previously
EC 1.17.1.7: Now EC 1.2.1.91, 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase
EC 1.17.1.8: 4-hydroxy-tetrahydrodipicolinate reductase
EC 1.17.1.9: formate dehydrogenase
EC 1.17.1.10: formate dehydrogenase (NADP⁺)
EC 1.17.1.11: formate dehydrogenase (NAD⁺, ferredoxin)

EC 1.17.2 With a cytochrome as acceptor

EC 1.17.3 With oxygen as acceptor

EC 1.17.4 With a disulfide as acceptor

EC 1.17.4.1: ribonucleoside-diphosphate reductase
EC 1.17.4.2: ribonucleoside-triphosphate reductase (thioredoxin)
EC 1.17.4.3: transferred to EC 1.17.7.1, (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase.
EC 1.17.4.4: vitamin-K-epoxide reductase (warfarin-sensitive)
EC 1.17.4.5: vitamin-K-epoxide reductase (warfarin-insensitive)

EC 1.17.5 With a quinone or similar compound as acceptor

EC 1.17.7 With an iron–sulfur protein as acceptor

EC 1.17.98 With other, known, physiological acceptors

EC 1.17.98.1: bile-acid 7α-dehydroxylase. Now known to be catalyzed by multiple enzymes.
EC 1.17.98.2: bacteriochlorophyllide c C-7¹-hydroxylase
EC 1.17.98.3: formate dehydrogenase (coenzyme F₄₂₀)
EC 1.17.98.4: formate dehydrogenase (hydrogenase)

EC 1.17.99 With unknown physiological acceptors

EC 1.17.99.1: Now EC 1.17.9.1, 4-methylphenol dehydrogenase (hydroxylating)
EC 1.17.99.2: ethylbenzene hydroxylase
EC 1.17.99.3: 3α,7α,12α-trihydroxy-5β-cholestanoyl-CoA 24-hydroxylase
EC 1.17.99.4: uracil/thymine dehydrogenase
EC 1.17.99.5: Now classified as EC 1.17.98.1, bile-acid 7α-dehydroxylase
EC 1.17.99.6: epoxyqueuosine reductase
EC 1.17.99.7: Now classified as EC 1.17.98.4, formate dehydrogenase (hydrogenase)
EC 1.17.99.8: limonene dehydrogenase
EC 1.17.99.9: heme a synthase
EC 1.17.99.10: steroid C-25 hydroxylase
EC 1.17.99.11: 3-oxo-Δ¹-steroid hydratase/dehydrogenase

EC 1.18 Acting on iron–sulfur proteins as donors

EC 1.18.1 With NAD⁺ or NADP⁺ as acceptor

EC 1.18.1.1: rubredoxin—NAD⁺ reductase
EC 1.18.1.2: ferredoxin—NADP⁺ reductase
EC 1.18.1.3: ferredoxin—NAD⁺ reductase
EC 1.18.1.4: rubredoxin—NAD(P)⁺ reductase
EC 1.18.1.5: Putidaredoxin—NAD⁺ reductase
EC 1.18.1.6: adrenodoxin-NADP⁺ reductase
EC 1.18.1.7: ferredoxin—NAD(P)⁺ reductase (naphthalene dioxygenase ferredoxin-specific)
EC 1.18.1.8: Now EC 7.2.1.2, ferredoxin—NAD⁺ oxidoreductase (Na⁺-transporting)

EC 1.18.2 With dinitrogen as acceptor (deleted sub-subclass)

EC 1.18.2.1: now EC 1.18.6.1, nitrogenase

EC 1.18.3 With H⁺ as acceptor (deleted sub-subclass)

EC 1.18.3.1: Now EC 1.12.7.2, ferredoxin hydrogenase

EC 1.18.6 With dinitrogen as acceptor

EC 1.18.96 With other, known, acceptors (deleted sub-subclass)

EC 1.18.96.1: Now EC 1.15.1.2, superoxide reductase

EC 1.18.99 With H⁺ as acceptor (deleted sub-subclass)

EC 1.18.99.1: Now EC 1.12.7.2, ferredoxin hydrogenase

EC 1.19 Acting on reduced flavodoxin as donor

EC 1.19.1 With NAD⁺ or NADP⁺ as acceptor

EC 1.19.1.1: flavodoxin—NADP⁺ reductase

EC 1.19.6 With dinitrogen as acceptor

EC 1.19.6.1: nitrogenase (flavodoxin)

EC 1.20 Acting on phosphorus or arsenic in donors

EC 1.20.1 Acting on phosphorus or arsenic in donors, with NAD⁺ as acceptor

EC 1.20.1.1: phosphonate dehydrogenase

EC 1.20.2 Acting on phosphorus or arsenic in donors, with NAD(P)⁺ as acceptor

EC 1.20.2.1: arsenate reductase (cytochrome c)

EC 1.20.4 Acting on phosphorus or arsenic in donors, with disulfide as acceptor

EC 1.20.9 With a copper protein as acceptor

EC 1.20.9.1: arsenate reductase (azurin)

EC 1.20.98 With other, known acceptors

EC 1.20.98.1: Now EC 1.20.9.1, arsenate reductase (azurin)

EC 1.20.99 With unknown physiological acceptors

EC 1.20.99.1: arsenate reductase (donor)

EC 1.21 Catalysing the reaction X-H + Y-H = X-Y

EC 1.21.3 With oxygen as acceptor

EC 1.21.3.1: isopenicillin-N synthase
EC 1.21.3.2: columbamine oxidase
EC 1.21.3.3: reticuline oxidase
EC 1.21.3.4: sulochrin oxidase ((+)-bisdechlorogeodin-forming)
EC 1.21.3.5: sulochrin oxidase ((-)-bisdechlorogeodin-forming)
EC 1.21.3.6: aureusidin synthase
EC 1.21.3.7: tetrahydrocannabinolic acid synthase
EC 1.21.3.8: cannabidiolic acid synthase
EC 1.21.3.9: now classified as EC 1.21.98.2, dichlorochromopyrrolate synthase

EC 1.21.4 With a disulfide as acceptor

EC 1.21.98 With other, known, physiological acceptors

EC 1.21.99 With unknown physiological acceptors

EC 1.21.99.1 EC 1.21.99.1: β-cyclopiazonate dehydrogenase
EC 1.21.99.2: Now classified as EC 1.21.98.1, cyclic dehypoxanthinyl futalosine synthase.
EC 1.21.99.3: thyroxine 5-deiodinase
EC 1.21.99.4: thyroxine 5′-deiodinase
EC 1.21.99.5: tetrachloroethene reductive dehalogenase

EC 1.22 Acting on halogen in donors

EC 1.22.1 With NAD⁺ or NADP⁺ as acceptor

EC 1.22.1.1: Now EC 1.21.1.1, iodotyrosine deiodinase

EC 1.23 Reducing C-O-C group as acceptor

EC 1.23.1 With NADH or NADPH as donor

EC 1.97 Other oxidoreductases

EC 1.97.1 Sole sub-subclass for oxidoreductases that do not belong in the other subclasses

EC 1.97.1.1: chlorate reductase
EC 1.97.1.2: pyrogallol hydroxytransferase
EC 1.97.1.3: Now EC 1.12.98.4, sulfhydrogenase, since hydrogen is known to be the electron donor
EC 1.97.1.4: [formate-C-acetyltransferase]-activating enzyme
EC 1.97.1.5: Now EC 1.20.4.1, arsenate reductase (glutaredoxin
EC 1.97.1.6: Now EC 1.20.99.1, arsenate reductase (donor)
EC 1.97.1.7: Now EC 1.20.4.2, methylarsonate reductase
EC 1.97.1.8: Now EC 1.21.99.5, tetrachloroethene reductive dehalogenase
EC 1.97.1.9: selenate reductase
EC 1.97.1.10: Now EC 1.21.99.4 thyroxine 5′-deiodinase
EC 1.97.1.11: Now EC 1.21.99.3 thyroxine 5-deiodinase.
EC 1.97.1.12: photosystem I

EC 1.98 Enzymes using H₂ as reductant (deleted subclass)

EC 1.98.1.1: Now EC 1.12.7.2, ferredoxin hydrogenase

EC 1.99 Other enzymes using O₂ as oxidant

EC 1.99.1 Hydroxylases (now covered by EC 1.14)

EC 1.99.1.1: deleted, Now EC 1.12.7.2, ferredoxin hydrogenase
EC 1.99.1.2: deleted, Now EC 1.14.16.1, phenylalanine 4-monooxygenase
EC 1.99.1.3: deleted, nicotinate 6-hydroxylase
EC 1.99.1.4: deleted, tryptophan 5-hydroxylase
EC 1.99.1.5: deleted, Now EC 1.14.13.9, kynurenine 3-monooxygenase
EC 1.99.1.6: deleted, steroid 11α-hydroxylase
EC 1.99.1.7: deleted, Now EC 1.14.15.4, steroid 11β-monooxygenase
EC 1.99.1.8: deleted, steroid 6β-hydroxylase
EC 1.99.1.9: deleted, Now EC 1.14.99.9, steroid 17α-monooxygenase
EC 1.99.1.10: deleted, steroid 19-hydroxylase
EC 1.99.1.11: deleted, Now EC 1.14.99.10, steroid 21-monooxygenase
EC 1.99.1.12: deleted, alkoxyaryl hydroxylase
EC 1.99.1.13: deleted, covered by EC 1.14.99.7 (squalene monooxygenase) and by EC 5.4.99.7 (lanosterol synthase)
EC 1.99.1.14: deleted, Now EC 1.13.11.27, 4-hydroxyphenylpyruvate dioxygenase

EC 1.99.2 Oxygenases (now covered by EC 1.13)

EC 1.99.2.1: deleted, now EC 1.13.11.12, lipoxygenase
EC 1.99.2.2: deleted, now EC 1.13.11.1, catechol 1,2-dioxygenase
EC 1.99.2.3: deleted, now EC 1.13.11.3, protocatechuate 3,4-dioxygenase
EC 1.99.2.4: deleted, now EC 1.13.11.4, gentisate 1,2-dioxygenase
EC 1.99.2.5: deleted, now EC 1.13.11.5, homogentisate 1,2-dioxygenase
EC 1.99.2.6: deleted, now EC 1.13.99.1, inositol oxygenase

References

^ "ExplorEnz – The Enzyme Database".
^ McDonald, A.G.; Boyce, S.; K.F., Tipton (2009). "ExplorEnz: the primary source of the IUBMB enzyme list". Nucleic Acids Res. 37 (Database issue): D593 – D597. doi:10.1093/nar/gkn582. PMC 2686581. PMID 18776214.

[1] "ExplorEnz – The Enzyme Database".

[2] McDonald, A.G.; Boyce, S.; K.F., Tipton (2009). "ExplorEnz: the primary source of the IUBMB enzyme list". Nucleic Acids Res. 37 (Database issue): D593 – D597. doi:10.1093/nar/gkn582. PMC 2686581. PMID 18776214.

[1]

[2]

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

v t e Oxidoreductases: alcohol oxidoreductases (EC 1.1)
1.1.1: NAD/NADP acceptor	3-hydroxyacyl-CoA dehydrogenase 3-hydroxybutyryl-CoA dehydrogenase Alcohol dehydrogenase Aldo-keto reductase 1A1 1B1 1B10 1C1 1C3 1C4 7A2 Aldose reductase Beta-Ketoacyl ACP reductase Carbohydrate dehydrogenases Carnitine dehydrogenase D-malate dehydrogenase (decarboxylating) DXP reductoisomerase Glucose-6-phosphate dehydrogenase Glycerol-3-phosphate dehydrogenase HMG-CoA reductase IMP dehydrogenase Isocitrate dehydrogenase Lactate dehydrogenase L-threonine dehydrogenase L-xylulose reductase Malate dehydrogenase Malate dehydrogenase (decarboxylating) Malate dehydrogenase (NADP+) Malate dehydrogenase (oxaloacetate-decarboxylating) Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) Phosphogluconate dehydrogenase Sorbitol dehydrogenase Hydroxysteroid dehydrogenase: 3β 3β-HSD NSDHL 11β 11β-HSD1 11β-HSD2 17β
1.1.2: cytochrome acceptor	D-lactate dehydrogenase (cytochrome) D-lactate dehydrogenase (cytochrome c-553) Mannitol dehydrogenase (cytochrome)
1.1.3: oxygen acceptor	Glucose oxidase L-gulonolactone oxidase Xanthine oxidase Alcohol oxidase
1.1.4: disulfide as acceptor	Vitamin K epoxide reductase Vitamin-K-epoxide reductase (warfarin-insensitive)
1.1.5: quinone/similar acceptor	Malate dehydrogenase (quinone) Quinoprotein glucose dehydrogenase
1.1.99: other acceptors	Choline dehydrogenase L2HGDH

v t e Aldehyde/oxo oxidoreductases (EC 1.2)
1.2.1: NAD or NADP	Aldehyde dehydrogenase Acetaldehyde dehydrogenase Long-chain-aldehyde dehydrogenase Mycothiol-dependent formaldehyde dehydrogenase
1.2.2: cytochrome	Formate dehydrogenase (cytochrome)
1.2.3: oxygen	Aldehyde oxidase
1.2.4: disulfide	Oxoglutarate dehydrogenase complex Pyruvate dehydrogenase Branched-chain alpha-keto acid dehydrogenase complex BCKDHA BCKDHB DBT DLD
1.2.7: iron–sulfur protein	Pyruvate synthase

v t e Oxidoreductases: CH–CH oxidoreductases (EC 1.3)
1.3.1: NAD/NADP acceptor	Enoyl-acyl carrier protein reductase/Enoyl ACP reductase 7-Dehydrocholesterol reductase Biliverdin reductase 2,4 Dienoyl-CoA reductase Dihydroxymethyloxo-tetrahydroquinoline dehydrogenase
1.3.3: Oxygen acceptor	Dihydroorotate dehydrogenase Coproporphyrinogen III oxidase Protoporphyrinogen oxidase Bilirubin oxidase Acyl-CoA oxidase Dihydrouracil oxidase Tetrahydroberberine oxidase Secologanin synthase Tryptophan alpha,beta-oxidase Pyrroloquinoline-quinone synthase L-galactonolactone oxidase
1.3.5: Quinone	Succinate dehydrogenase SDHA SDHB SDHC SDHD
1.3.99: Other acceptors	Fumarate reductase Butyryl-CoA dehydrogenase Acyl CoA dehydrogenase ACADSB ACADS 5α-reductase SRD5A1 SRD5A2 SRD5A3 Glutaryl-CoA dehydrogenase Isovaleryl coenzyme A dehydrogenase 3-oxo-5beta-steroid 4-dehydrogenase

v t e CH-NH₂ oxidoreductases (EC 1.4) - primarily amino acid oxidoreductases
1.4.1: NAD/NADP acceptor	Glutamate dehydrogenase GLUD1 GLUD2 Glutamate synthase (NADPH)
1.4.3: oxygen acceptor	D-amino acid oxidase Amine oxidase (Copper-containing (Lysyl Diamine Primary-amine)) (Flavin-containing (Monoamine)))
1.4.4: disulfide acceptor	Glycine cleavage system
1.4.99: other acceptors	D-amino acid dehydrogenase Amine dehydrogenase