Inositol-1,4-bisphosphate 1-phosphatase
| inositol-1,4-bisphosphate 1-phosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.3.57 | ||||||||
| CAS no. | 111070-17-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme inositol-1,4-bisphosphate 1-phosphatase (EC 3.1.3.57) catalyzes the reaction
- 1D-myo-inositol 1,4-bisphosphate + H2O 1D-myo-inositol 4-phosphate + phosphate
This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name is D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase. This enzyme is also called inositol-polyphosphate 1-phosphatase. This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system.
Structural studies
[edit]As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1INP and 1JP4.
References
[edit]- Berridge MJ, Dawson RM, Downes CP, Heslop JP, Irvine RF (1983). "Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides". Biochem. J. 212 (2): 473–82. doi:10.1042/bj2120473. PMC 1152070. PMID 6309146.
- Connolly TM, Bansal VS, Bross TE, Irvine RF, Majerus PW (1987). "The metabolism of tris- and tetraphosphates of inositol by 5-phosphomonoesterase and 3-kinase enzymes". J. Biol. Chem. 262 (5): 2146–9. doi:10.1016/S0021-9258(18)61629-1. PMID 3029066.
- Inhorn RC, Majerus PW (1987). "Inositol polyphosphate 1-phosphatase from calf brain. Purification and inhibition by Li+, Ca2+, and Mn2+". J. Biol. Chem. 262 (33): 15946–52. doi:10.1016/S0021-9258(18)47680-6. PMID 2824473.
